Impact of the COVID-19 pandemic on liver transplant waitlist outcome in France - Archive ouverte HAL
Article Dans Une Revue Scientific Reports Année : 2023

Impact of the COVID-19 pandemic on liver transplant waitlist outcome in France

Camille Legeai
Corinne Antoine
Carine Jasseron
François Kerbaul
Jérôme Dumortier

Résumé

Abstract The objective of this study was to investigate the impact of the COVID-19 pandemic on the outcome of patients on the liver transplantation (LT) waitlist in 2020 in France, in particular, the incidence of deaths and delisting for worsening condition, depending on the allocation score component. The 2020 cohort of patients on the waiting list was compared with the 2018/2019 cohorts. 2020 saw fewer LTs than in either 2019 or 2018 (1128, 1356, and 1325, respectively), together with fewer actual brain dead donors (1355, 1729, and 1743). In 2020, deaths or delisting for worsening condition increased significantly versus 2018/2019 (subdistribution hazard ratio 1.4, 95% confidence interval [CI] 1.2–1.7), after adjustment for age, place of care, diabetes, blood type, and score component, although COVID-19-related mortality was low. This increased risk mainly concerned patients with hepatocellular carcinoma (1.52, 95% CI 1.22–1.90), with 650 MELD exception points (2.19, 95% CI 1.08–4.43), and especially those without HCC and MELD scores from 25 to 30 (3.36 [95% CI 1.82–6.18]). In conclusion, by significantly decreasing LT activity in 2020, the COVID-19 pandemic increased the number of waitlist deaths and delisting for worsening condition, and significantly more for particular components of the score, including intermediate severity cirrhosis.

Dates et versions

hal-04183847 , version 1 (21-08-2023)

Identifiants

Citer

Camille Legeai, Corinne Antoine, Carine Jasseron, François Kerbaul, Jérôme Dumortier. Impact of the COVID-19 pandemic on liver transplant waitlist outcome in France. Scientific Reports, 2023, 13 (1), pp.9308. ⟨10.1038/s41598-023-32680-8⟩. ⟨hal-04183847⟩

Collections

HCL HEH
28 Consultations
0 Téléchargements

Altmetric

Partager

More