Article Dans Une Revue Archives of cardiovascular diseases Année : 2023

Cardiogenic shock in adults with congenital heart disease: Insights from the FRENSHOCK registry

1 UPS/Inserm U1297 - I2MC - Institut des Maladies Métaboliques et Casdiovasculaires
2 Service Cardiologie pédiatrique [CHU Toulouse]
3 Service Cardiologie [CHU Toulouse]
4 HEGP - Hôpital Européen Georges Pompidou [APHP]
5 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
6 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
7 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
8 AMU - Aix Marseille Université
9 Hôpital Nord [CHU - APHM]
10 MARS cardio - Mediterranean Association for Research and Studies in Cardiology
11 LTSI - Laboratoire Traitement du Signal et de l'Image
12 Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes]
13 Service de Réanimation Médicale [CHRU Nancy]
14 Group Ramsay-générale de santé
15 IMRB - Institut Mondor de Recherche Biomédicale
16 Hôpital de Hautepierre [Strasbourg]
17 Service de réanimation médicale polyvalente [CHU Cochin]
18 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
19 Service d'anesthésie et de réanimation [Hôpital de la Timone - APHM]
20 Service de cardiologie [CHRU de Besançon]
21 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
22 Hôpital de la Croix-Rousse [CHU - HCL]
23 Département de cardiologie [CHU de Grenoble]
24 CH de Saint-Malo [Broussais]
25 HUS - Hôpitaux Universitaires de Strasbourg
26 Service Cardiologie Médicale et Médecine Vasculaire [CHU Clermont-Ferrand]
27 Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire [Strasbourg]
28 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
29 CHU Amiens-Picardie
30 CHBA - Centre hospitalier Bretagne Atlantique (Morbihan)
31 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
32 USMR - Unité de Soutien Méthodologique à la Recherche [CHU Toulouse]
33 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
Laurent Leborgne
Vanina Bongard

Résumé

Background: Data on cardiogenic shock in adults with congenital heart disease (ACHD) are scarce. Aim: We sought to describe cardiogenic shock in ACHD patients in a nationwide cardiogenic shock registry. Methods: From the multicentric FRENSHOCK registry (772 patients with cardiogenic shock from 49 French centres between April and October 2016), ACHD patients were compared with adults without congenital heart disease (non-ACHD). The primary outcome was defined by all-cause mortality, chronic ventricular assist device or heart transplantation at 1year. Results: Out of the 772 patients, seven (0.9%) were ACHD, who were younger (median age: 56 vs. 67years), had fewer cardiovascular risk factors, such as hypertension (14.3% vs. 47.5%) and diabetes (14.3% vs. 28.3%), and no previous ischaemic cardiopathy (0 vs. 61.5%). Right heart catheterization (57.1% vs. 15.4%), pacemakers (28.6% vs. 4.6%) and implantable cardioverter-defibrillators (28.6% vs. 4.8%) were indicated more frequently in the management of ACHD patients compared with non-ACHD patients, whereas temporary mechanical circulatory support (0 vs. 18.7%) and invasive mechanical ventilation (14.3% vs. 38.1%) were less likely to be used in ACHD patients. At 1year, the primary outcome occurred in 85.7% (95% confidence interval: 42.1-99.6) ACHD patients and 52.3% (95% confidence interval: 48.7-55.9) non-ACHD patients. Although 1-year mortality was not significantly different between ACHD patients (42.9%) and non-ACHD patients (45.4%), ventricular assist devices and heart transplantation tended to be more frequent in the ACHD group. Conclusions: Cardiogenic shock in ACHD patients is rare, accounting for only 0.9% of an unselected cardiogenic shock population. Despite being younger and having fewer co-morbidities, the prognosis of ACHD patients with cardiogenic shock remains severe, and is similar to that of other patients.

Fichier principal
Vignette du fichier
2023 Karsenty et al., Cardiogenic.pdf (719.8 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-04183605 , version 2 (21-08-2023)
hal-04183605 , version 1 (09-11-2023)

Licence

Identifiants

Citer

Clément Karsenty, Anthony Touafchia, Magalie Ladouceur, François Roubille, Eric Bonnefoy, et al.. Cardiogenic shock in adults with congenital heart disease: Insights from the FRENSHOCK registry. Archives of cardiovascular diseases, In press, 116 (8-9), pp.390-396. ⟨10.1016/j.acvd.2023.06.008⟩. ⟨hal-04183605v2⟩
251 Consultations
366 Téléchargements

Altmetric

Partager

  • More