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Article Dans Une Revue NMR in Biomedicine Année : 2023

NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants

Résumé

Abstract Nowadays, exposure to endocrine‐disrupting chemicals (EDCs), including persistent organic pollutants (POPs), is one of the most critical threats to public health. EDCs are chemicals that mimic, block, or interfere with hormones in the body's endocrine system and have been associated with a wide range of health issues. This innovative, untargeted metabolomics study investigates chronic low‐dose internal exposure to a cocktail of POPs on multiple tissues that are known to accumulate these lipophilic compounds. Interestingly, the metabolic response differs among selected tissues/organs in mice. In the liver, we observed a dynamic effect according to the exposure time and the doses of POPs. In the brain tissue, the situation is the opposite, leading to the conclusion that the presence of POPs immediately gives a saturated effect that is independent of the dose and the duration of exposure studied. By contrast, for the adipose tissues, nearly no effect is observed. This metabolic profiling leads to a holistic and dynamic overview of the main metabolic pathways impacted in lipophilic tissues by a cocktail of POPs.

Dates et versions

hal-04182525 , version 1 (17-08-2023)

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Covadonga Lucas-Torres, Cédric Caradeuc, Laura Prieur, Haidar Djemai, Layale Youssef, et al.. NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants. NMR in Biomedicine, 2023, ⟨10.1002/nbm.5006⟩. ⟨hal-04182525⟩
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