Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease - Archive ouverte HAL
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease

Résumé

Estrogen-related receptors (ERRα, β and γ in mammals) are orphan members of the nuclear receptor superfamily acting as transcription factors. ERRs are expressed in several cell types and they display various functions in normal and pathological contexts. Amongst others, they are notably involved in bone homeostasis, energy metabolism and cancer progression. In contrast to other nuclear receptors, the activities of the ERRs are apparently not controlled by a natural ligand but they rely on other means such as the availability of transcriptional co-regulators. Here we focus on ERRα and review the variety of co-regulators that have been identified by various means for this receptor and their reported target genes. ERRα cooperates with distinct co-regulators to control the expression of distinct sets of target genes. This exemplifies the combinatorial specificity of transcriptional regulation that induces discrete cellular phenotypes depending on the selected coregulator. We finally propose an integrated view of the ERRα transcriptional network.
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Dates et versions

hal-04176601 , version 1 (03-08-2023)

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Catherine Cerutti, Jing-Ru Shi, Jean-Marc Vanacker. Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease. International Journal of Molecular Sciences, 2023, 24 (5), pp.4265. ⟨10.3390/ijms24054265⟩. ⟨hal-04176601⟩
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