Temporal constraints in associative synaptic plasticity in hippocampus and neocortex - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Canadian Journal of Physiology and Pharmacology Année : 1995

Temporal constraints in associative synaptic plasticity in hippocampus and neocortex

Résumé

We present comparative experimental evidence for the induction of synaptic potentiation and depression in organotypic cultures of hippocampus and in visual cortex in vitro and in vivo. The effects of associative pairings on the efficacy of synaptic transmission are analyzed as a function of the temporal delay between presynaptic activity and post-synaptic changes imposed in membrane potential. Synchronous association at a low temporal frequency (<0.5 Hz) between presynaptic input and postsynaptic depolarization resulted in homosynaptic potentiation of functionally identified postsynaptic potentials in the three types of preparation. Synchronous pairing of afferent activity with hyperpolarization of the postsynaptic cell resulted in homosynaptic depression in visual cortex in vivo and in vitro. An associative form of depression was induced in hippocampus when the test input was followed repeatedly with a fixed-delay postsynaptic depolarization imposed either by intracellular current injection or synaptically. The latter process might play a significant role in heterosynaptic plasticity in visual cortex in vivo and in vitro, if it is assumed that associative depression still operates in visual cortex a few seconds after the initial surge of calcium in the postsynaptic cell. We conclude that the precise timing between presynaptic activity and polarization changes in postsynaptic membrane potential up- and down-regulates the efficacy of active pathways.Key words: synaptic potentiation, synaptic depression, asynchrony, covariance, supervised learning.
Fichier non déposé

Dates et versions

hal-04174273 , version 1 (31-07-2023)

Identifiants

Citer

Dominique Debanne, Daniel Shulz, Yves Frégnac. Temporal constraints in associative synaptic plasticity in hippocampus and neocortex. Canadian Journal of Physiology and Pharmacology, 1995, 73 (9), pp.1295-1311. ⟨10.1139/y95-185⟩. ⟨hal-04174273⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More