Early alterations of diabetic mouse aortas revealed by X-ray micro-CT
Résumé
Diabetes is a major concern of our society that affects about 10% of the world population. Elastic fiber alterations due to diabetes increase the stiffness of large arteries through poorly understood structural alterations. To address this issue, we used synchrotron X-ray microtomography (μ-CT) with in-line phase contrast to image, in three dimensions, control and diabetic mice aorta with a voxel size of 650 nm and a field diameter and height of 1.3 mm. Image analysis shows that, in older diabetic mice, the elastic lamellae lose their internal scaffolds to become smoother. This suggests a link between the loss of their 3D lattice-like network and the reduction of their elasticity.
Domaines
Imagerie| Origine | Accord explicite pour ce dépôt |
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