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Article Dans Une Revue Chemistry - A European Journal Année : 2023

Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation

Résumé

Among the general interest in fluorinated compounds, trifluoromethoxylated molecules play a specific role. However, despite this interest, the development of efficient reagents to perform trifluoromethoxylation reactions remains a challenge. Here, 2,4-dinitro-trifluoromethoxybenzene (DNTFB) is used as a trifluoromethoxylating reagent to perform nucleophilic substitution under mild metal-free conditions with different leaving groups, including direct dehydroxytrifluoromethoxylation. A mechanistic study rationalized the reaction and subsequently proposed only three reaction conditions, depending on the reactivity of the starting substrates.

Domaines

Chimie organique
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Dates et versions

hal-04165325 , version 1 (18-07-2023)

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Clémence Bonnefoy, Armen Panossian, Gilles Hanquet, Frédéric Leroux, Fabien Toulgoat, et al.. Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation. Chemistry - A European Journal, inPress, ⟨10.1002/chem.202301513⟩. ⟨hal-04165325⟩
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