How does the inner retinal network shape the ganglion cells receptive field : a computational study
Résumé
We consider a model of basic inner retinal connectivity where bipolar and
amacrine cells interconnect, and both cell types project onto ganglion cells, mod-
ulating their response output to the brain visual areas. We derive an analytical
formula for the spatio-temporal response of retinal ganglion cells to stimuli taking
into account the effects of amacrine cells inhibition. This analysis reveals two im-
portant functional parameters of the network: (i) the intensity of the interactions
between bipolar and amacrine cells, and, (ii) the characteristic time scale of these
responses. Both parameters have a profound combined impact on the spatiotem-
poral features of RGC responses to light. The validity of the model is confirmed by
faithfully reproducing pharmacogenetic experimental results obtained by stimulat-
ing excitatory DREADDs (Designer Receptors Exclusively Activated by Designer
Drugs) expressed on ganglion cells and amacrine cells subclasses, thereby modi-
fying the inner retinal network activity to visual stimuli in a complex, entangled
manner. Our mathematical model allows us to explore and decipher these complex
effects in a manner that would not be feasible experimentally and provides novel
insights in retinal dynamics.
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY - Paternité
Licence : CC BY - Paternité