This study is part of a research project aiming at developing advanced functions of medication related CDSS to support the monitoring of patients' therapeutic treatments based mainly on corresponding lab values. We adopted a user-centred approach to the design of these advanced CDSS functions. We collected existing recommendations in the literature and completed previous Human Factors (HF) field studies and analyses by focused observations and modeling. We present resulting HF based recommendations for the design of such advanced medication CDSS and focus more specifically on two innovative high level recommendations completing those already existing in the literature. For illustration purposes, an example of the operationalization of one of the recommendation is presented.