Introduction: According to the World Health Organization, chronic diseases would be responsible for 52 million deaths by 2030 (OMS, 2014). Sedentary behaviour and physical inactivity are modifiable risk factors at the forefront of prevention and health promotion strategies (OMS, 2018). The health benefits of physical activity (PA) are widely demonstrated in chronic diseases (INSERM, 2019) and have leading to the prescription of adapted physical activities (APA). Despite encouraging international data (Knobé, 2019; Pedersen & Saltin, 2006) french scientific data are insufficient to evaluate the effectiveness of programs relating to APA prescription. Our study aims to evaluate the ”Bougez sur ordonnance® ” program with two objectives: 1. to measure the effectiveness of the program based, 2. to identify the patient profiles for whom the program would be most beneficial. Methods: Our sample was composed of 113 participants with a chronic disease (83.18% women) with a mean age of 55.4 ± 13.9 years. The participants benefited from an 8-week PA program that could include Nordic walking, aqua fitness, gymnastic or stretching. All participants were evaluated at the beginning and end of the program including anthropometric measurements (e.g weight and waist circumference) and subjective measure of physical activity. Physical fitness was also assessed in three key areas such as aerobic fitness (e.g 2 or 6 minutes walking test); muscular strength and endurance (e.g 30 Second Sit to Stand Test) and flexibility (e.g Fingertip-to-Floor distance). Results and discussion: Nearly 86% of participants were overweight with a body mass index (BMI) greater than 25 kg/m² and two thirds had a BMI up to 30 kg/m2. Statistical analyses showed a significant improvement in the physical condition of the participants, expressed by a better cardiorespiratory endurance, a better flexibility, and an increase in the muscular strength of the lower limbs. The level of PA increased significantly for all participants. Conclusion : The significant improvement at the end of the APA prescription is encouraging. These results corroborate those obtained in the international literature and allow us to add to the few studies that still exist in France. Yet, these results need to be confirmed by a long-term evaluation of the effectiveness of the APA prescription. INSERM. (2019). Activité physique, Prévention et traitement des maladies chroniques. Retrieved from http://repositorio.unan.edu.ni/2986/1/5624.pdf Knobé, S. (2019). La prescription médicale d’activité physique et perspectives socio-écologiques Exercise on prescription: a systematic review and socio-ecological perspectives. 31. WHO. (2014). GLOBAL STATUS REPORT on noncommunicable diseases 2014 - Attaining the nine global noncommunicable diseases targets; a shared responsibility. (GENEVA), 280. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/148114/9789241564854 eng.pdf;jsessionid=B3B3 OMS. (2018). Plan d’action mondial de l’oms pour promouvoir l’activité physique 2018-2030. Pedersen, B. K., & Saltin, B. (2006). Evidence for prescribing exercise as therapy in chronic disease. Scandinavian Journal of Medicine and Science in Sports, 16(SUPPL. 1), 3–63. https://doi.org/10.1111/j.1600-0838.2006.00520.x