Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
Résumé
In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gutassociated lymphoid tissues toward tumors.
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