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Journal Articles Nature Methods Year : 2023

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

Bálint Mészáros
András Hatos
Nicolas Palopoli
  • Function : Author
Federica Quaglia
  • Function : Author
Edoardo Salladini
Kim van Roey
  • Function : Author
Haribabu Arthanari
Zsuzsanna Dosztányi
  • Function : Author
Isabella C Felli
  • Function : Author
Patrick D Fischer
  • Function : Author
Jeffrey C Hoch
  • Function : Author
Cy M Jeffries
Emiliano Maiani
Sandra Orchard
Rita Pancsa
  • Function : Author
Elena Papaleo
  • Function : Author
Roberta Pierattelli
Damiano Piovesan
  • Function : Author
Iva Pritisanac
  • Function : Author
Luiggi Tenorio
  • Function : Author
Thibault Viennet
Peter Tompa
Wim Vranken
Silvio C E Tosatto
Norman E Davey

Abstract

An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.
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Dates and versions

hal-04154454 , version 1 (07-07-2023)

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Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, et al.. Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions. Nature Methods, In press, ⟨10.1038/s41592-023-01915-x⟩. ⟨hal-04154454⟩
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