Basicity‐Controlled [3+2] Cyclization of 3‐Hydroxyquinolin‐ones and β‐Chlorinated Nitrostyrenes
Résumé
The construction of novel skeletons through the recombination of natural products ring systems is attractive. Herein, a basicitycontrolled synthesis of (dihydro)furo[2,3-c]quinolin-4(5H)-one derivatives through (3 + 2) cyclization between 3-hydroxyquino-lin-2-ones and β-chlorinated nitrostyrenes was developed. In addition, preliminary study gave the chiral dihydrofuro[2,3c]quinolin-4(5H)-one derivatives with up to 83 % ee.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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