Article Dans Une Revue Cancers Année : 2022

Prognostic Impact of Microscopic Extra-Thyroidal Extension (mETE) on Disease Free Survival in Patients with Papillary Thyroid Carcinoma (PTC)

Nadia Bouzehouane
  • Fonction : Auteur
Myriam Decaussin-Petrucci
Mireille Bertholon-Grégoire
  • Fonction : Auteur
Chantal Bully
  • Fonction : Auteur
Agnès Perrin
  • Fonction : Auteur
Helene Lasolle
  • Fonction : Auteur
Jean-Christophe Lifante
Françoise Borson-Chazot
Claire Bournaud
  • Fonction : Auteur

Résumé

Background: This study assessed the risk of reduced disease-free survival (DFS) and poor clinical outcome in patients with papillary thyroid carcinomas (PTC) with microscopic extra-thyroidal extension (mETE), as compared to PTC patients without mETE. Methods: Retrospective analysis of a prospective database of patients treated by total thyroidectomy and radioactive iodine (RAI) with a five-year follow-up and tumors < 40 mm. In total, 303 patients were analyzed: 30.7% presented tumors with mETE, and 69.3% without. mETE was defined as extra-thyroidal invasion without skeletal muscle involvement. The primary outcome, DFS, was defined as the interval between initial treatment and any subsequent PTC-related treatment. The second outcome was the clinical status at five years. Results: In univariate analyses, the five-year DFS was significantly lower for tumors with mETE (62.4% versus 88.1%, p < 0.001). In multivariate analysis, mETE and massive lymph node involvement (LNI) were independent prognostic factors, associated respectively with a hazard ratio of 2.55 (95% CI 1.48–4.40) and 8.94 (95% CI 4.92–16.26). mETE was significantly associated with a pejorative clinical outcome at five years, i.e., biochemical/indeterminate response and structural persistence (Respectively OR 1.83 (95% CI 0.83; 4.06) and OR 4.92 (95% CI 1.87; 12.97)). Conclusion: Our results suggest that mETE is an independent poor prognosis factor of reduced DFS and predictive of poor clinical outcome.

Fichier principal
Vignette du fichier
main.pdf (720.45 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04152358 , version 1 (01-04-2025)

Licence

Identifiants

Citer

Nadia Bouzehouane, Pascal Roy, Myriam Decaussin-Petrucci, Mireille Bertholon-Grégoire, Chantal Bully, et al.. Prognostic Impact of Microscopic Extra-Thyroidal Extension (mETE) on Disease Free Survival in Patients with Papillary Thyroid Carcinoma (PTC). Cancers, 2022, 14 (11), pp.2591. ⟨10.3390/cancers14112591⟩. ⟨hal-04152358⟩
69 Consultations
132 Téléchargements

Altmetric

Partager

  • More