Regulations on reporting research misconduct have undergone a remarkable process of development since the 1980s. At the same time, many states have also developed legislation governing the receiving of alerts and for protecting whistleblowers against reprisal. Although these two bodies of legislation share the aim of organising the practice of reporting, they have been developed in isolation from each other, and without sufficient thought as to how they should be linked. Based on an analysis of European Union law and its transposition in France, this article identifies the convergences and divergences between whistleblowing legislation and the reporting of research misconduct. It then looks at the contributions that each body of law can make to the other, both in terms of the procedures applicable and the protection afforded to whistleblowers. The lessons learned from the comparison of whistleblowing law and the procedures for reporting scientific misconduct allow for the identification of avenues for improvement.