Exploring damaged elastic arteries by Synchrotron X-ray Micro-CT
Résumé
Diabetes is a chronic pathology affecting about 10% of the world population. Large arteries such as the aorta contain, in their extracellular matrix, an amorphous elastic hydrophobic polymer named elastin, which is the major component of elastic fibers. In-line phase-contrast synchrotron X-ray microtomography of the arterial wall with labelfree tissues grants access to fine details of elastic structures. Coupled to an automatic image analysis program, this technique provides information that cannot be obtained using other imaging methods. Our results show that the reserve length of elastic lamellae is reduced in diabetic mice together with the loss of filaments that support the wall. This suggests that elasticity is correlated to the existence of this lattice-like network that has disappeared at 6 months of diabetes.
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