Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat - Archive ouverte HAL
Article Dans Une Revue AJP - Gastrointestinal and Liver Physiology Année : 2002

Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat

Résumé

A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv, respectively) Transit of the methylcellulose liquid solution was also accelerated by ghrelin/MTLRP in the small intestine but not in the colon. Des-[Gln(14)]ghrelin, also found in the mammalian stomach, was as potent as ghrelin in emptying the stomach (gastric residue after 15 min: 12 +/- 3% at a dose of 20 microg/kg iv). In rats in which postoperative gastrointestinal ileus had been experimentally induced, ghrelin/MTLRP (20 microg/kg iv) reversed the delayed gastric evacuation (gastric residue after 15 min: 28 +/- 7% of the ingested meal vs. 82 +/- 9% with saline). In comparison, the gastric ileus was not modified by high doses of motilin (77 +/- 7%) or erythromycin (82 +/- 6%) and was only partially improved by calcitonin gene-related peptide (CGRP) 8-37 antagonist (59 +/- 7%). Ghrelin/MTLRP, therefore, accelerates the gastric emptying and small intestinal transit of a liquid meal and is a strong prokinetic agent capable of reversing the postoperative gastric ileus in rat.
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hal-04146331 , version 1 (29-06-2023)

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Louise Trudel, Catherine Tomasetto, Marie-Christine Rio, Mickaël Bouin, Victor Plourde, et al.. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. AJP - Gastrointestinal and Liver Physiology, 2002, 282 (6), pp.G948-952. ⟨10.1152/ajpgi.00339.2001⟩. ⟨hal-04146331⟩
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