The parapineal mediates left-right asymmetry in the zebrafish diencephalon - Archive ouverte HAL
Article Dans Une Revue Development (Cambridge, England) Année : 2003

The parapineal mediates left-right asymmetry in the zebrafish diencephalon

Résumé

The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ – the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae,show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.

Dates et versions

hal-04144706 , version 1 (28-06-2023)

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Joshua Gamse, Christine Thisse, Bernard Thisse, Marnie Halpern. The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development (Cambridge, England), 2003, 130 (6), pp.1059-1068. ⟨10.1242/dev.00270⟩. ⟨hal-04144706⟩
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