Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Science Translational Medicine Année : 2023

Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination

Résumé

The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein-specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein-specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced TH1 polarization of their SARS-CoV-2 spike protein-specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein-specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein-specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.
Fichier principal
Vignette du fichier
ris00002274.pdf (2.75 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04144641 , version 1 (28-06-2023)

Identifiants

Citer

Véronique Barateau, Loïc Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, et al.. Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination. Science Translational Medicine, 2023, 15 (687), 17 p. ⟨10.1126/scitranslmed.ade0550⟩. ⟨hal-04144641⟩
34 Consultations
35 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More