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Article Dans Une Revue Science Translational Medicine Année : 2023

Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination

Résumé

The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein-specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein-specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced TH1 polarization of their SARS-CoV-2 spike protein-specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein-specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein-specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.
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Dates et versions

hal-04144641 , version 1 (28-06-2023)

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Véronique Barateau, Loïc Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, et al.. Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination. Science Translational Medicine, 2023, 15 (687), 17 p. ⟨10.1126/scitranslmed.ade0550⟩. ⟨hal-04144641⟩
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