Sexy splicing: regulatory interplays governing sex determination from <i>Drosophila</i> to mammals - Archive ouverte HAL Access content directly
Journal Articles Journal of Cell Science Year : 2003

Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals

Abstract

A remarkable array of strategies is used to produce sexual differentiation in different species. Complex gene hierarchies govern sex determination pathways, as exemplified by the classic D. melanogaster paradigm,where an interplay of transcriptional, splicing and translational mechanisms operate. Molecular studies support the hypothesis that genetic sex determination pathways evolved in reverse order, from downstream to upstream genes, in the cascade. The recent identification of a role for the key regulatory factors SRY and WT1(+KTS) in pre-mRNA splicing indicates that important steps in the mammalian sex determination process are likely to operate at the post-transcriptional level.

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Biochemistry, Molecular Biology

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https://hal.science/hal-04142309

Submitted on : Monday, June 26, 2023-6:27:53 PM

Last modification on : Thursday, June 29, 2023-11:18:34 AM

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hal-04142309 , version 1 (26-06-2023)

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Enzo Lalli, Kenji Ohe, Elisa Latorre, Marco Bianchi, Paolo Sassone-Corsi. Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals. Journal of Cell Science, 2003, 116 (3), pp.441-445. ⟨10.1242/jcs.00249⟩. ⟨hal-04142309⟩

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