Neuronal Store-Operated Calcium Channels - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Neurobiology Année : 2023

Neuronal Store-Operated Calcium Channels

Résumé

The endoplasmic reticulum (ER) is the major intracellular calcium (Ca2+) storage compartment in eukaryotic cells. In most instances, the mobilization of Ca2+ from this store is followed by a delayed and sustained uptake of Ca2+ through Ca2+-permeable channels of the cell surface named store-operated Ca2+ channels (SOCCs). This gives rise to a store-operated Ca2+ entry (SOCE) that has been thoroughly investigated in electrically non-excitable cells where it is the principal regulated Ca2+ entry pathway. The existence of this Ca2+ route in neurons has long been a matter of debate. However, a growing body of experimental evidence indicates that the recruitment of Ca2+ from neuronal ER Ca2+ stores generates a SOCE. The present review summarizes the main studies supporting the presence of a depletion-dependent Ca2+ entry in neurons. It also addresses the question of the molecular composition of neuronal SOCCs, their expression, pharmacological properties, as well as their physiological relevance.

Domaines

Neurobiologie
Fichier non déposé

Dates et versions

hal-04141765 , version 1 (26-06-2023)

Identifiants

Citer

Alexandre Bouron. Neuronal Store-Operated Calcium Channels. Molecular Neurobiology, 2023, 60, pp.4517-4546. ⟨10.1007/s12035-023-03352-5⟩. ⟨hal-04141765⟩
13 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More