Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation - Archive ouverte HAL
Journal Articles Molecular Cell Year : 2004

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

Abstract

LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin E1 promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.

Dates and versions

hal-04139884 , version 1 (23-06-2023)

Identifiers

Cite

Oronza A. Botrugno, Elisabeth Fayard, Jean-Sébastien Annicotte, Céline Haby, Thomas Brennan, et al.. Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Molecular Cell, 2004, 15 (4), pp.499-509. ⟨10.1016/j.molcel.2004.07.009⟩. ⟨hal-04139884⟩
6 View
0 Download

Altmetric

Share

More