Retinoic-acid-induced apoptosis in leukemia cells - Archive ouverte HAL
Journal Articles Trends in Molecular Medicine Year : 2004

Retinoic-acid-induced apoptosis in leukemia cells

Abstract

Retinoic acid (RA) cures more than 75% of patients with acute promyelocytic leukemia (APL). Here, we review the various anti-cancer activities of retinoids and rexinoids, alone and in combination with other drugs, with emphasis on the RA-dependent induction of a cancer-cell-selective apoptosis signaling pathway to which multiple anti-cancer signals converge. These findings identify the TRAIL (tumor-necrosis-factor-related apoptosis-inducing ligand) pathway as a central cell-autonomous anti-cancer weapon that can act independently of the immune system.

Dates and versions

hal-04138428 , version 1 (22-06-2023)

Identifiers

Cite

Ana Jiménez-Lara, Nicole Clarke, Lucia Altucci, Hinrich Gronemeyer. Retinoic-acid-induced apoptosis in leukemia cells. Trends in Molecular Medicine, 2004, 10 (10), pp.508-515. ⟨10.1016/j.molmed.2004.08.006⟩. ⟨hal-04138428⟩
17 View
0 Download

Altmetric

Share

More