Retinoids: potential in cancer prevention and therapy - Archive ouverte HAL
Journal Articles Expert Reviews in Molecular Medicine Year : 2004

Retinoids: potential in cancer prevention and therapy

Abstract

Retinoids (derivatives of vitamin A) are signalling molecules that play important roles in cell growth, differentiation and death. Retinoids act through two types of receptors - retinoic acid receptors (RAR alpha, RAR beta and RAR gamma) and retinoid X receptors (RXR alpha, RXR beta and RXR gamma) - which themselves act as ligand-dependent transcription factors. Retinoids are of special interest in cancer research owing to their antiproliferative and cancer-preventative properties. They have been used successfully to cure acute promyelocytic leukaemia (APL) and can suppress carcinogenesis in a variety of tissue types (e.g. skin, lung, breast and oral cancers). Extensive research efforts have been dedicated to elucidating the molecular and cellular networks that are induced by retinoids, and this has recently yielded novel insights into how retinoids can both prevent and combat cancer.
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Dates and versions

hal-04138426 , version 1 (22-06-2023)

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Nicole Clarke, Pierre Germain, Lucia Altucci, Hinrich Gronemeyer. Retinoids: potential in cancer prevention and therapy. Expert Reviews in Molecular Medicine, 2004, 6 (25), pp.1-23. ⟨10.1017/S1462399404008488⟩. ⟨hal-04138426⟩
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