Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression - Archive ouverte HAL
Journal Articles Genes and Development Year : 2004

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression

Abstract

We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre fused to a modified estrogen receptor (CreER(T2)). 4-Hydroxy-tamoxifen treatment induced fak deletion in the epidermis, and suppressed chemically induced skin tumor formation. Loss of fak induced once benign tumors had formed inhibited malignant progression. Although fak deletion was associated with reduced migration of keratinocytes in vitro, we found no effect on wound re-epithelialization in vivo. However, increased keratinocyte cell death was observed after fak deletion in vitro and in vivo. Our work provides the first experimental proof implicating FAK in tumorigenesis, and this is associated with enhanced apoptosis.

Domains

Genetics

Dates and versions

hal-04138419 , version 1 (22-06-2023)

Identifiers

Cite

Gordon W. Mclean, Noboru H. Komiyama, Bryan Serrels, Hidefumi Asano, Louise Reynolds, et al.. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes and Development, 2004, 18 (24), pp.2998-3003. ⟨10.1101/gad.316304⟩. ⟨hal-04138419⟩
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