Conference Papers Year : 2023

Optical Diffraction Tomography Meets Fluorescence Localization Microscopy

Thanh-An Pham
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  • PersonId : 1026958
Emmanuel Soubies
Michael Unser

Abstract

We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the illumination sources are fluorophores within the sample. Building upon this model, we propose a joint optimization framework to estimate both the refractive index map and the position of fluorescent molecules from the sole SMLM frames.
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Dates and versions

hal-04132428 , version 1 (19-06-2023)

Identifiers

  • HAL Id : hal-04132428 , version 1

Cite

Thanh-An Pham, Emmanuel Soubies, Ferréol Soulez, Michael Unser. Optical Diffraction Tomography Meets Fluorescence Localization Microscopy. 1st International Symposium on Computational Sensing (ISCS 2023), Jun 2023, Luxembourg, Luxembourg. ⟨hal-04132428⟩
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