Optical Diffraction Tomography Meets Fluorescence Localization Microscopy - Archive ouverte HAL Access content directly
Conference Papers Year : 2023

Optical Diffraction Tomography Meets Fluorescence Localization Microscopy

Thanh-An Pham
  • Function : Author
  • PersonId : 1026958
Emmanuel Soubies
Michael Unser
  • Function : Author
  • PersonId : 866714

Abstract

We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the illumination sources are fluorophores within the sample. Building upon this model, we propose a joint optimization framework to estimate both the refractive index map and the position of fluorescent molecules from the sole SMLM frames.
Fichier principal
Vignette du fichier
Abstract_ISCS.pdf (2.14 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-04132428 , version 1 (19-06-2023)

Identifiers

  • HAL Id : hal-04132428 , version 1

Cite

Thanh-An Pham, Emmanuel Soubies, Ferréol Soulez, Michael Unser. Optical Diffraction Tomography Meets Fluorescence Localization Microscopy. 1st International Symposium on Computational Sensing (ISCS 2023), Jun 2023, Luxembourg, Luxembourg. ⟨hal-04132428⟩
45 View
16 Download

Share

Gmail Facebook X LinkedIn More