Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability - Archive ouverte HAL
Journal Articles Brain Structure and Function Year : 2023

Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability

1 ARAMIS - Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
2 CIBM - Center for Biomedical Imaging [Lausanne]
3 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
4 EMPENN - Neuroimagerie: méthodes et applications
5 ICM - Institut du Cerveau = Paris Brain Institute
6 Queensland Brain Institute
7 CHU Pitié-Salpêtrière [AP-HP]
8 University Hospital Mannheim | Universitätsmedizin Mannheim
9 Trinity College Dublin
10 King‘s College London
11 NEUROSPIN - Service NEUROSPIN
12 University of Vermont [Burlington]
13 UON - University of Nottingham, UK
14 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
15 PTB - Physikalisch-Technische Bundesanstalt [Berlin]
16 INSERM - Institut National de la Santé et de la Recherche Médicale
17 CB - CB - Centre Borelli - UMR 9010
18 Medizinische Fakultät Mannheim
19 TU Dresden - Technische Universität Dresden = Dresden University of Technology
20 Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada]
21 UMG - University Medical Center Göttingen
22 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
23 BIH - Berlin Institute of Health
24 UNIL - Université de Lausanne = University of Lausanne
25 SU - Sorbonne Université
26 CNRS - Centre National de la Recherche Scientifique
27 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
Antoine Grigis
  • Function : Author
Herve Lemaitre
  • Function : Author
Vincent Frouin
  • Function : Author

Abstract

The temporo-basal region of the human brain is composed of the collateral, the occipitotemporal, and the rhinal sulci. We manually rated (using a novel protocol) the connections between rhinal/collateral (RS-CS), collateral/occipito-temporal (CS-OTS) and rhinal/occipito-temporal (RS-OTS) sulci, using the MRI of nearly 3,400 individuals including around 1000 twins. We reported both the associations between sulcal polymorphisms as well with a wide range of demographics (e.g. age, sex, handedness). Finally, we also estimated the heritability, and the genetic correlation between sulcal connections. We reported the frequency of the sulcal connections in the general population, which were hemisphere dependent. We found a sexual dimorphism of the connections, especially marked in the right hemisphere, with a CS-OTS connection more frequent in females (approximately 35-40% versus 20-25% in males) and an RS-CS connection more common in males (approximately 40-45% versus 25-30% in females). We confirmed associations between sulcal connections and characteristics of incomplete hippocampal inversion (IHI). We estimated the broad sense heritability to be 0.28-0.45 for RS-CS and CS-OTS connections, with hints of dominant contribution for the RS-CS connection. The connections appeared to share some of their genetic causing factors as indicated by strong genetic correlations. Heritability appeared much smaller for the (rarer) RS-OTS connection.
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hal-04132176 , version 1 (18-06-2023)

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Kevin de Matos, Claire Cury, Lydia Chougar, Lachlan T Strike, Thibault Rolland, et al.. Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability. Brain Structure and Function, 2023, 228 (6), pp.1459-1478. ⟨10.1007/s00429-023-02663-6⟩. ⟨hal-04132176⟩
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