Cyclops-independent floor plate differentiation in zebrafish embryos - Archive ouverte HAL
Journal Articles Developmental Dynamics Year : 2003

Cyclops-independent floor plate differentiation in zebrafish embryos

Stéphanie Albert
  • Function : Author
Ferenc Müller
  • Function : Author
Nadine Fischer
  • Function : Author
Carl Neumann
  • Function : Author
Patrick Blader
Uwe Strähle
  • Function : Author

Abstract

In zebrafish, development of the ventral neural tube depends on the Nodal-related signal Cyclops (Cyc). One-day-old cyc mutant embryos lack the medial floor plate (MFP). We show here that cells expressing MFP marker genes differentiate gradually in cyc mutant embryos in a delayed manner during the second day of development. This late differentiation is restricted to the hindbrain and spinal cord and depends on an intact Hedgehog (Hh) signalling pathway. Cells expressing MFP marker genes in cyc mutant embryos appear to be derived from lateral floor plate (LFP) cells as they coexpress LFP and MFP marker genes. This finding suggests that the correct temporal development of the MFP is required for the distinction of LFP and MFP cells in wild-type embryos.
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Dates and versions

hal-04130438 , version 1 (15-06-2023)

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Stéphanie Albert, Ferenc Müller, Nadine Fischer, Dominique Biellmann, Carl Neumann, et al.. Cyclops-independent floor plate differentiation in zebrafish embryos. Developmental Dynamics, 2003, 226 (1), pp.59-66. ⟨10.1002/dvdy.10211⟩. ⟨hal-04130438⟩
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