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Poster De Conférence Année : 2022

Ferrocifen loaded Nanoparticles: Targeting MDR tumors via the Thioredoxin Reductase Pathway

Résumé

Regardless of the leaps being achieved in the field of cancer treatment, 90% of the failures of chemotherapy arise from the multidrug resistance aspect gained by the tumors 1. Aiming to overcome these limitations, ferrocifens, a family of molecules obtained chemically by combination of one ferrocene with hydroxytamoxifen derivatives 2 , encapsulated in lipid nanocapsules, could offer an innovative and promising approach to combat this resistance. Moreover, the functionalization of the obtained nanoparticles with polyethylene glycol would imbue them with stealth properties 3 , increasing their half-life and blood circulation time, while utilizing the enhanced permeability and retention effect (EPR) to improve the internalization into cancer cells 4. Ferrocifen has been hypothesized to act via targeting the thioredoxin reductase (TrxR), a system responsible for thiol redox homeostasis and overexpressed in cancer cells, leading to an increased resistance 5,6. This action might stem from TrxR displaying a selenocysteine residue at its C-terminal active site, which can be targeted by metal complexes. This project, alongside producing ferrocifen loaded nanoparticles, aims to verify and establish the mode of action of this active substance on TrxR, using different genetic and molecular experimental techniques.
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Dates et versions

hal-04127365 , version 1 (14-06-2023)

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Milad Baroud, Elise Lepeltier, Anne Vessieres, Nicolas Clere, Gérard Jaouen, et al.. Ferrocifen loaded Nanoparticles: Targeting MDR tumors via the Thioredoxin Reductase Pathway. SFNano 2022, Dec 2022, Strasbourg, France. 130, pp.146 - 153, 2008, ⟨10.1016/j.jconrel.2008.05.027⟩. ⟨hal-04127365⟩
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