Management of Tuberculosis Infection: Current Situation, Recent Developments and Operational Challenges - Archive ouverte HAL
Article Dans Une Revue Pathogens Année : 2023

Management of Tuberculosis Infection: Current Situation, Recent Developments and Operational Challenges

Résumé

Tuberculosis infection (TBI) is defined as a state of infection in which individuals host live Mycobacterium tuberculosis with or without clinical signs of active TB. It is now understood as a dynamic process covering a spectrum of responses to infection resulting from the interaction between the TB bacilli and the host immune system. The global burden of TBI is about one-quarter of the world's population, representing a reservoir of approximately 2 billion people. On average, 5-10% of people who are infected will develop TB disease over the course of their lives, but this risk is enhanced in a series of conditions, such as co-infection with HIV. The End-TB strategy promotes the programmatic management of TBI as a crucial endeavor to achieving global targets to end the TB epidemic. The current development of new diagnostic tests capable of discriminating between simple TBI and active TB, combined with novel short-course preventive treatments, will help achieve this goal. In this paper, we present the current situation and recent developments of management of TBI and the operational challenges.
Fichier principal
Vignette du fichier
Gino. pathogens_2023.pdf (522.67 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04123908 , version 1 (09-06-2023)

Licence

Identifiants

Citer

Gino Agbota, Maryline Bonnet, Christian Lienhardt. Management of Tuberculosis Infection: Current Situation, Recent Developments and Operational Challenges. Pathogens, 2023, 12 (3), pp.362. ⟨10.3390/pathogens12030362⟩. ⟨hal-04123908⟩
12 Consultations
71 Téléchargements

Altmetric

Partager

More