Portage conjonctival du SARS-CoV-2 chez les patients atteints de formes asymptomatiques ou non sévères de COVID-19 (COVIDEYE) - Archive ouverte HAL
Article Dans Une Revue Journal Français d'Ophtalmologie Année : 2023

Portage conjonctival du SARS-CoV-2 chez les patients atteints de formes asymptomatiques ou non sévères de COVID-19 (COVIDEYE)

Résumé

Introduction: The prevalence of ocular conveyance of SARS-CoV-2 has been well described for severe/hospitalized cases, but scarcely reported in asymptomatic and non-severe patients, who are unaware that they are carriers. Material & methods: This prospective cross-sectional study quantitatively evaluated SARS-CoV-2 shedding on the ocular surface (OS). Conjunctival testing was suggested to all hospital personnel being screened by nasopharyngeal (NP) SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR). Disease symptoms were evaluated using a standardized questionnaire and telephone follow-up 6 ± 3 months later for disease evolution (recovery with/without severe disease). Results: Four hundred and eighty seven patients were included. From 46 NP SARS-CoV-2-positive subjects (cycle threshold [CT] = 24.2 ± 7.1), 13% tested positive at the OS (CT = 36.4 ± 2.8). Most SARS-CoV-2-positive subjects were symptomatic (n = 40, 87%), while 6 were asymptomatic (being tested as contact cases). Systemic symptoms were not significantly different in OS-positive vs OS-negative subjects, although headache tended to be more frequent in OS-positives (83% vs 54%, P = 0.06). None of the OS-positive subjects reported ocular symptoms and none developed severe disease requiring hospitalization or oxygen therapy. Conclusion: SARS-CoV-2 shedding at the OS may occur in asymptomatic and non-severe COVID-19 individuals (including those absent of ocular symptoms). However, the high RT-PCR CT values attained may indicate a low risk of transmissibility via this route.

Dates et versions

hal-04122502 , version 1 (08-06-2023)

Identifiants

Citer

Alain P. Rousseau, Christelle Vauloup-Fellous, Oscar L. Haigh, Stéphan Pavy, D. Molinari, et al.. Portage conjonctival du SARS-CoV-2 chez les patients atteints de formes asymptomatiques ou non sévères de COVID-19 (COVIDEYE). Journal Français d'Ophtalmologie, 2023, 46 (2), pp.101-105. ⟨10.1016/j.jfo.2022.09.018⟩. ⟨hal-04122502⟩
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