Article Dans Une Revue Cancer Année : 2023

Risk of subsequent primary lymphoma in a cohort of 69,460 five-year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

1 University of Birmingham [Birmingham]
2 Princess Máxima Center for Pediatric Oncology [Utrecht, Netherlands]
3 UNIBE - Universität Bern = University of Bern = Université de Berne
4 UNIL - Université de Lausanne = University of Lausanne
5 St. Anna Children's Hospital - Saint Anna Children's Hospital [Vienne] = St Anna Kinderspital
6 JKU - University of Linz - Johannes Kepler Universität Linz
7 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
8 DCSRC - Danish Cancer Society Research Center
9 Landspitali National University Hospital of Iceland
10 Newcastle Upon Tyne Hospitals NHS Foundation Trust
11 Newcastle University [Newcastle]
12 UNILU - Université de Lucerne = Universität Luzern
13 Oslo University Hospital [Oslo]
14 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
15 UMCL - University Medical Centre Ljubljana
16 RadboudUMC - Radboud University Medical Center [Nijmegen]
17 Skane University Hospital [Lund]
18 UNITO - Università degli studi di Torino = University of Turin
19 Azienda Ospedalerio - Universitaria Città della Salute e della Scienza di Torino = University Hospital Città della Salute e della Scienza di Torino
20 CESP - Centre de recherche en épidémiologie et santé des populations
21 IGR - Institut Gustave Roussy
22 JGU - Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
23 Semmelweis University [Budapest]
24 Cancer Registry of Norway
25 IRCCS Istituto Nazionale dei Tumori [Milano]
26 Institute of Oncology [Ljubljana]
27 Inselspital - Bern University Hospital [Berne]
28 Emma Children’s Hospital
29 University of Turku
30 Aarhus University [Aarhus]
Julianne M. Byrne
  • Fonction : Auteur
Lorna Zaletel
Päivi Maria Lähteenmäki

Résumé

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non-Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan-European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and Follow-Up Studies (PanCareSurFup) cohort includes 69,460 five-year survivors of childhood cancer, diagnosed during 1940 through 2008, from 12 European countries. Risks of SPLs were quantified by standardized incidence ratios (SIRs) and relative risks (RRs) using multivariable Poisson regression. Results: Overall, 140 SPLs, including 104 NHLs and 36 HLs, were identified. Survivors were at 60% increased risk of an SPL compared with the general population (SIR, 1.6; 95% confidence interval [CI], 1.4–1.9). Survivors were twice as likely to develop NHL (SIR, 2.3; 95% CI, 1.9–2.8), with the greatest risks among survivors of HL (SIR, 7.1; 95% CI, 5.1–10.0), Wilms tumor (SIR, 3.1; 95% CI, 1.7–5.7), leukemia (SIR, 2.8; 95% CI, 1.8–4.4), and bone sarcoma (SIR, 2.7; 95% CI, 1.4–5.4). Treatment with chemotherapy for any cancer doubled the RR of NHL (RR, 2.1; 95% CI, 1.2–3.9), but treatment with radiotherapy did not (RR, 1.2; 95% CI, 0.7–2.0). Survivors were at similar risk of developing a subsequent HL as the general population (SIR, 1.1; 95% CI, 0.8–1.5). Conclusions: In addition to HL, the authors show here for the first time that survivors of Wilms tumor, leukemia, and bone sarcoma are at risk of NHL. Survivors and health care professionals should be aware of the risk of NHL in these survivors and in any survivors treated with chemotherapy.

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hal-04122464 , version 1 (04-07-2023)

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Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, et al.. Risk of subsequent primary lymphoma in a cohort of 69,460 five-year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study. Cancer, 2023, 129 (3), pp.426-440. ⟨10.1002/cncr.34561⟩. ⟨hal-04122464⟩
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