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Article Dans Une Revue Annales Pharmaceutiques Françaises Année : 2015

The topological pressure-temperature phase diagram of ritonavir, an extraordinary case of crystalline dimorphism

Résumé

A topological pressure-temperature phase diagram involving the phase relationships of ritonavir forms I and II has been constructed using experimental calorimetric and volumetric data available from the literature. The triple point I-II-liquid is located at a temperature of about 407 K and a pressure as extraordinarily small as 17.5 MPa (175 bar). Thus, the less soluble solid phase (form II) will become metastable on increasing pressure. At room temperature, form I becomes stable around 100 MPa indicating that form II may turn into form I at a relatively low pressure of 1000 bar, which may occur under processing conditions such as mixing or grinding. This case is a good example for which a proper thermodynamic evaluation trumps "rules of thumb" such as the density rule.

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Chimie
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Dates et versions

hal-04119534 , version 1 (06-06-2023)

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R. Céolin, Ivo B. Rietveld. The topological pressure-temperature phase diagram of ritonavir, an extraordinary case of crystalline dimorphism. Annales Pharmaceutiques Françaises, 2015, 73 (1), pp.22-30. ⟨10.1016/j.pharma.2014.09.003⟩. ⟨hal-04119534⟩
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