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Article Dans Une Revue ACS Applied Materials & Interfaces Année : 2011

In vitro Studies and Preliminary In vivo Evaluation of Silicified Concentrated Collagen Hydrogels

Résumé

Hybrid and nanocomposite silica collagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblasts while decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silica collagen biomaterials as biological dressings.

Domaines

Chimie

Dates et versions

hal-04119153 , version 1 (06-06-2023)

Identifiants

Citer

Martín Desimone, Christophe Hélary, Sandrine Quignard, Ivo B. Rietveld, Isabelle Bataille, et al.. In vitro Studies and Preliminary In vivo Evaluation of Silicified Concentrated Collagen Hydrogels. ACS Applied Materials & Interfaces, 2011, 3 (10), pp.3831-3838. ⟨10.1021/am2009844⟩. ⟨hal-04119153⟩
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