T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo - Archive ouverte HAL Access content directly
Journal Articles International Immunology Year : 2001

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

Abstract

The role of IL-4, -6 and -7 in the survival of T lymphocytes was studied in vivo. The decay of polyclonal populations of CD4(+) and CD8(+) T cells was monitored in thymectomized anti-cytokine receptor mAb-treated and/or cytokine-deficient mice. The lack of IL-4 or -6 did not have any detectable effect on T cell survival, but IL-7 played an important role in the survival of the naive T cell compartment, especially of naive CD4(+) T cells.

Dates and versions

hal-04119054 , version 1 (06-06-2023)

Identifiers

Cite

Laëtitia Vivien, Christophe Benoist, Diane Mathis. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. International Immunology, 2001, 13 (6), pp.763-768. ⟨10.1093/intimm/13.6.763⟩. ⟨hal-04119054⟩
6 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More