Trajectories of the evolution of post COVID-19 condition, up to two years after symptoms onset - Archive ouverte HAL
Article Dans Une Revue International Journal of Infectious Diseases Année : 2023

Trajectories of the evolution of post COVID-19 condition, up to two years after symptoms onset

Résumé

Objectives We aimed to identify trajectories of the evolution of post-COVID-19 condition, up to 2 years after symptom onset. Methods The ComPaRe long COVID e-cohort is a prospective cohort of patients with symptoms lasting at least 2 months after SARS-CoV2 infection. We used trajectory modeling to identify different trajectories in the evolution of post-COVID-19 condition, based on symptoms collected every 60 days using the long COVID Symptom Tool. Results A total of 2197 patients were enrolled in the cohort between December 2020 and July 2022 when the Omicron variant was not dominant. Three trajectories of the evolution of post-COVID-19 condition were identified: “high persistent symptoms” (4%), “rapidly decreasing symptoms” (5%), and “slowly decreasing symptoms” (91%). Participants with highly persistent symptoms were older and more likely to report a history of systemic diseases. They often reported tachycardia, bradycardia, palpitations, and arrhythmia. Participants with rapidly decreasing symptoms were younger and more likely to report a confirmed infection. They often reported diarrhea and back pain. Participants with slowly decreasing symptoms were more likely to have a history of functional diseases. Conclusion Most patients with post-COVID-19 condition improve slowly over time, while 5% have rapid improvement in the 2 years after symptom onset and 4% have a persistent condition.
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hal-04106905 , version 1 (30-08-2023)

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Clemence Servier, Raphaël Porcher, Isabelle Pane, Philippe Ravaud, Viet-Thi Tran. Trajectories of the evolution of post COVID-19 condition, up to two years after symptoms onset. International Journal of Infectious Diseases, 2023, 133, pp.67-74. ⟨10.1016/j.ijid.2023.05.007⟩. ⟨hal-04106905⟩
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