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Article Dans Une Revue Journal of Clinical Medicine Année : 2023

Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study

Résumé

Background: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36). Results: We included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0–45.5) and a median disease duration of 7 years (1.8–11.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9/19, 47.4%), somatization (8/19, 42.1%) and phobia (5/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Behçet’s patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6/9 patients did not have any complaint of memory loss and were thus considered ansognostic. Conclusion: Cognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

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hal-04106350 , version 1 (02-06-2023)

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Fanny Urbain, Isabelle Hardy-Léger, Ghaidaa Adebs-Nasser, Mathilde de Menthon, Cécile Pivert, et al.. Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study. Journal of Clinical Medicine, 2023, 12 (9), ⟨10.3390/jcm12093149⟩. ⟨hal-04106350⟩
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