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                <term xml:lang="en">incidence</term>
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              <p>Aims: In the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR-HA incidence in France and to describe both its characteristics and preventability.Methods: A prospective multicentre study was conducted among randomly selected French public hospital medical wards (April-July 2018). Patients admitted during a week period were included. ADR-HA cases were collected by the French Regional Pharmacovigilance Centres network. An independent committee validated potential cases and ADR preventability.Results: ADR-HA incidence was 8.5% (95% confidence interval [CI]: 7.6-9.4%), increasing with age (3.3% [95%CI: 1.8-5.5%] ≤16 y vs. 10.6% [95%CI: 9.3-12.0%] ≥65 y). The most common ADRs were haemorrhagic events (8.8%), haematological disorders (6.5%), acute renal failure (6.3%), fluid and electrolyte disorders (6.0%), and falls (5.2%). New drugs were involved: targeted therapies (22.8% of antineoplastics), direct oral anticoagulants (29.6% of antithrombotics) and incretin-based drugs (20.0% of antidiabetics). ADRs were preventable in 16.1% of cases because the drugs involved had not been used in accordance with monographies, package leaflets or other therapeutic guidelines. The main situations of noncompliance addressed either dose or duration of use (27.9%), warning (23.2%), use precaution (18.6%) and inappropriate self-medication or misuse by patients (11.6%).Conclusion: In France, ADR-HA incidence dramatically increased over the last decade. A significant proportion was related to new pharmacological classes and considered as preventable. These findings should lead to in-depth thought on preventive actions on at-risk drug classes.</p>
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          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
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          <idno type="ROR">https://ror.org/00ph8tk69</idno>
          <orgName>Hôpital Cochin [AP-HP]</orgName>
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            <address>
              <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
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          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
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            <ref type="url">http://www.sorbonne-universite.fr/</ref>
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            <address>
              <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
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          <orgName>Institut Desbrest d'Epidémiologie et de Santé Publique</orgName>
          <orgName type="acronym">IDESP</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Institut Universitaire de Recherche Clinique641 Avenue du Doyen Gaston Giraud34093 Montpellier</addrLine>
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          <orgName>CHU Montpellier = Montpellier University Hospital</orgName>
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            <address>
              <addrLine>371, avenue du Doyen Gaston Giraud 34295 MONTPELLIER cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-montpellier.fr</ref>
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        <org type="institution" xml:id="struct-300157" status="VALID">
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          <orgName type="acronym">CHRU Nancy</orgName>
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            <ref type="url">http://www.chu-nancy.fr</ref>
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        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
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            <ref type="url">http://www.chu-angers.fr/</ref>
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          <orgName>Centre Hospitalier Régional Universitaire de Tours</orgName>
          <orgName type="acronym">CHRU Tours</orgName>
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            <address>
              <addrLine>Centre Hospitalier Régional Universitaire de Tours2 Boulevard Tonnellé 37044 Tours cedex 9</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.chu-tours.fr/</ref>
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          <orgName>OmégaHealth</orgName>
          <orgName type="acronym">ΩHealth</orgName>
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          <desc>
            <address>
              <addrLine>Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/omegahealth/</ref>
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          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
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              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.chu-rennes.fr/</ref>
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          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
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            <ref type="url">http://www.inserm.fr</ref>
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          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
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            <ref type="url">http://www.umontpellier.fr/</ref>
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          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
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            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
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</TEI>