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Article Dans Une Revue (Article De Synthèse) Trends in Genetics Année : 2023

Genomics in the long-read sequencing era

Résumé

Long-read sequencing (LRS) technologies have provided extremely powerful tools to explore genomes. While in the early years these methods suffered technical limitations, they have recently made significant progress in terms of read length, throughput, and accuracy and bioinformatics tools have strongly improved. Here, we aim to review the current status of LRS technologies, the development of novel methods, and the impact on genomics research. We will explore the most impactful recent findings made possible by these technologies focusing on high-resolution sequencing of genomes and transcriptomes and the direct detection of DNA and RNA modifications. We will also discuss how LRS methods promise a more comprehensive understanding of human genetic variation, transcriptomics, and epigenetics for the coming years.
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Dates et versions

hal-04103984 , version 1 (23-05-2023)

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Erwin van Dijk, Delphine Naquin, Kévin Gorrichon, Yan Jaszczyszyn, Rania Ouazahrou, et al.. Genomics in the long-read sequencing era. Trends in Genetics, 2023, 39 (9), pp.649-671. ⟨10.1016/j.tig.2023.04.006⟩. ⟨hal-04103984⟩
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