An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomedicine and Pharmacotherapy Année : 2023

An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes

Résumé

Bacterial resistance development represents a serious threat to human health across the globe and has become a very serious clinical problem for many classes of antibiotics. Hence, there is a constant and urgent need for the discovery and development of new effective antibacterial agents to stem the emergence of resistant bacteria. 1,4-naphthoquinones are an important class of natural products and have been known for decades as a privileged scaffold in medicinal chemistry regarding their many biological properties. The significant biological properties of specific 1,4-naphthoquinones hydroxyderivatives have drawn the attention of researchers in order to find new derivatives with an optimized activity, mainly as antibacterial agents. Based on juglone, naphthazarin, plumbagin and lawsone moieties, structural optimization was realized with the purpose of improving the antibacterial activity. Thereupon, relevant antibacterial activities have been observed on different panels of bacterial strains including resistant ones. In this review, we highlight the interest of developing new 1,4-naphthoquinones hydroxyderivatives and some metal complexes as promising antibacterial agents alternatives. Here, we thoroughly report for the first time both the antibacterial activity and the chemical synthesis of four different 1,4-naphthoquinones (juglone, naphthazarin, plumbagin and lawsone) from 2002 to 2022 with an emphasis on the structure-activity relationship, when applicable.
Fichier principal
Vignette du fichier
2023_Majdi_BiomedPharmTh_OA_dep.pdf (9.15 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale

Dates et versions

hal-04100606 , version 1 (23-05-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Chaimae Majdi, Valentin Duvauchelle, Patrick Meffre, Zohra Benfodda. An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes. Biomedicine and Pharmacotherapy, 2023, 162, pp.114690. ⟨10.1016/j.biopha.2023.114690⟩. ⟨hal-04100606⟩

Collections

UNIMES
38 Consultations
25 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More