<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04100206</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T23:13:26+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells</title>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <forename type="middle">A</forename>
                <surname>Fraunhoffer</surname>
              </persName>
              <idno type="halauthorid">2263656-0</idno>
              <affiliation ref="#struct-179570"/>
              <affiliation ref="#struct-131288"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aura I</forename>
                <surname>Moreno Vega</surname>
              </persName>
              <idno type="halauthorid">2814286-0</idno>
              <affiliation ref="#struct-321644"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Analía Meilerman</forename>
                <surname>Abuelafia</surname>
              </persName>
              <idno type="halauthorid">2054379-0</idno>
              <affiliation ref="#struct-179570"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Morvan</surname>
              </persName>
              <idno type="halauthorid">1142368-0</idno>
              <affiliation ref="#struct-101"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Émilie</forename>
                <surname>Lebarbier</surname>
              </persName>
              <email type="md5">834c91eed20fc7a608b2ee4f02d07831</email>
              <email type="domain">parisnanterre.fr</email>
              <idno type="idhal" notation="string">emilie-lebarbier</idno>
              <idno type="idhal" notation="numeric">744214</idno>
              <idno type="halauthorid" notation="string">844032-744214</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9170-5836</idno>
              <idno type="IDREF">https://www.idref.fr/083747907</idno>
              <affiliation ref="#struct-101"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tristan</forename>
                <surname>Mary-Huard</surname>
              </persName>
              <email type="md5">fdd646bc37bf70f7888a088f07c50921</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">tristanmary-huard</idno>
              <idno type="idhal" notation="numeric">748716</idno>
              <idno type="halauthorid" notation="string">35572-748716</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3839-9067</idno>
              <idno type="IDREF">https://www.idref.fr/22754093X</idno>
              <affiliation ref="#struct-1002311"/>
              <affiliation ref="#struct-1002313"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Zimmermann</surname>
              </persName>
              <email type="md5">137f25d57be6b8e76139878e09f873b0</email>
              <email type="domain">iaas.uni-stuttgart.de</email>
              <idno type="idhal" notation="numeric">1096561</idno>
              <idno type="halauthorid" notation="string">966002-1096561</idno>
              <affiliation ref="#struct-572475"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gwen</forename>
                <surname>Lomberk</surname>
              </persName>
              <idno type="idhal" notation="numeric">1196425</idno>
              <idno type="halauthorid" notation="string">699041-1196425</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5463-789X</idno>
              <affiliation ref="#struct-572475"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Raul</forename>
                <surname>Urrutia</surname>
              </persName>
              <email type="md5">32340bd3be8c47f53466f16f2c45d197</email>
              <email type="domain">mayo.edu</email>
              <idno type="idhal" notation="numeric">938373</idno>
              <idno type="halauthorid" notation="string">230298-938373</idno>
              <affiliation ref="#struct-572475"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nelson</forename>
                <surname>Dusetti</surname>
              </persName>
              <email type="md5">6be9233460a12de2672ab1281c3f9536</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">758392</idno>
              <idno type="halauthorid" notation="string">220939-758392</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6161-8483</idno>
              <idno type="IDREF">https://www.idref.fr/15184013X</idno>
              <affiliation ref="#struct-179570"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yuna</forename>
                <surname>Blum</surname>
              </persName>
              <email type="md5">0a45899a9c4261572ebe444bd94589d5</email>
              <email type="domain">univ-rennes1.fr</email>
              <idno type="idhal" notation="string">yuna-blum</idno>
              <idno type="idhal" notation="numeric">1192321</idno>
              <idno type="halauthorid" notation="string">444284-1192321</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4716-8017</idno>
              <affiliation ref="#struct-187162"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rémy</forename>
                <surname>Nicolle</surname>
              </persName>
              <email type="md5">fb8e8b172b7cb82f8d95909582c0616e</email>
              <email type="domain">ligue-cancer.net</email>
              <idno type="idhal" notation="string">remy-nicolle</idno>
              <idno type="idhal" notation="numeric">774086</idno>
              <idno type="halauthorid" notation="string">913694-774086</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8084-1173</idno>
              <idno type="IDREF">https://www.idref.fr/199783926</idno>
              <idno type="VIAF">https://viaf.org/viaf/182149717556610951654</idno>
              <affiliation ref="#struct-1005007"/>
              <affiliation ref="#struct-162876"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Juan</forename>
                <surname>Iovanna</surname>
              </persName>
              <email type="md5">266a04f9ccecb3fdf64f1f955621cb15</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">932201</idno>
              <idno type="halauthorid" notation="string">669529-932201</idno>
              <affiliation ref="#struct-179570"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder>This work was supported by INCa (Grants number 2018-078 to ND and 2018- 079 to JI), Canceropole PACA (ND), Amidex Foundation (ND), and INSERM (JI).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-11-21 15:18:06</date>
              <date type="whenModified">2026-03-13 14:29:58</date>
              <date type="whenReleased">2023-11-21 15:18:07</date>
              <date type="whenProduced">2023-05-04</date>
              <date type="whenEndEmbargoed">2023-11-21</date>
              <ref type="file" target="https://hal.science/hal-04100206v1/document">
                <date notBefore="2023-11-21"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04100206v1/file/2023_priming_ebiomedicine.pdf" id="file-4297976-3749038">
                <date notBefore="2023-11-21"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.1016/j.ebiom.2023.104602"/>
              <fs>
                <f name="inra_etatDocument_local" notation="numeric">
                  <numeric>0</numeric>
                </f>
                <f name="inra_etatDocument_local" notation="string" n="0">
                  <string>inra_etatDocument_local_0</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04100206</idno>
            <idno type="halUri">https://hal.science/hal-04100206</idno>
            <idno type="halBibtex">fraunhoffer:hal-04100206</idno>
            <idno type="halRefHtml">&lt;i&gt;EBioMedicine&lt;/i&gt;, 2023, 92, pp.104602. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ebiom.2023.104602"&gt;&amp;#x27E8;10.1016/j.ebiom.2023.104602&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">EBioMedicine, 2023, 92, pp.104602. &amp;#x27E8;10.1016/j.ebiom.2023.104602&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc-nd/4.0/">CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works<ref corresp="#file-4297976-3749038"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="AGROPARISTECH">AgroParisTech</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="UNIV-PARIS10" corresp="UNIV-PARIS-LUMIERES">Université Paris Nanterre</idno>
            <idno type="stamp" n="INSMI">CNRS-INSMI - INstitut des Sciences Mathématiques et de leurs Interactions</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="IGDR">Institut Génétique et Développement de Rennes</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="MIA-PARIS">MIA-Paris</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UPN">Collection supérieure de l'université Paris Nanterre</idno>
            <idno type="stamp" n="GQE" corresp="AGROPARISTECH">Génétique Quantitative et Evolution - Le Moulon</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="MODALX" corresp="UNIV-PARIS10">MODAL'X - UMR 9023 - Modélisation aléatoire de Paris Nanterre</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="AMIDEX">AMIDEX</idno>
            <idno type="stamp" n="CRCM">Centre de Recherche en Cancérologie de Marseille</idno>
            <idno type="stamp" n="UNIV-PARIS-LUMIERES"/>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-PARIS-NANTERRE" corresp="UNIV-PARIS-LUMIERES">Université Paris Nanterre</idno>
            <idno type="stamp" n="GS-MATHEMATIQUES">Graduate School Mathématiques</idno>
            <idno type="stamp" n="GS-COMPUTER-SCIENCE">Graduate School Computer Science</idno>
            <idno type="stamp" n="GS-BIOSPHERA">Graduate School Biologie, Société, Ecologie &amp; Environnement, Ressources, Agriculture &amp; Alimentation</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="BGC" corresp="IGDR">Biologie et génétique du cancer</idno>
            <idno type="stamp" n="MATHNUM">Département MathNum</idno>
            <idno type="stamp" n="BIOLOGIE_ET_AMELIORATION_DES_PLANTES">Département BAP INRAE</idno>
            <idno type="stamp" n="TEST-MATHNUM">Test MathNum</idno>
            <idno type="stamp" n="APT_TEST">APT_TEST</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <forename type="middle">A</forename>
                    <surname>Fraunhoffer</surname>
                  </persName>
                  <idno type="halauthorid">2263656-0</idno>
                  <affiliation ref="#struct-179570"/>
                  <affiliation ref="#struct-131288"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aura I</forename>
                    <surname>Moreno Vega</surname>
                  </persName>
                  <idno type="halauthorid">2814286-0</idno>
                  <affiliation ref="#struct-321644"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Analía Meilerman</forename>
                    <surname>Abuelafia</surname>
                  </persName>
                  <idno type="halauthorid">2054379-0</idno>
                  <affiliation ref="#struct-179570"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Morvan</surname>
                  </persName>
                  <idno type="halauthorid">1142368-0</idno>
                  <affiliation ref="#struct-101"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Émilie</forename>
                    <surname>Lebarbier</surname>
                  </persName>
                  <email type="md5">834c91eed20fc7a608b2ee4f02d07831</email>
                  <email type="domain">parisnanterre.fr</email>
                  <idno type="idhal" notation="string">emilie-lebarbier</idno>
                  <idno type="idhal" notation="numeric">744214</idno>
                  <idno type="halauthorid" notation="string">844032-744214</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9170-5836</idno>
                  <idno type="IDREF">https://www.idref.fr/083747907</idno>
                  <affiliation ref="#struct-101"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tristan</forename>
                    <surname>Mary-Huard</surname>
                  </persName>
                  <email type="md5">fdd646bc37bf70f7888a088f07c50921</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">tristanmary-huard</idno>
                  <idno type="idhal" notation="numeric">748716</idno>
                  <idno type="halauthorid" notation="string">35572-748716</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3839-9067</idno>
                  <idno type="IDREF">https://www.idref.fr/22754093X</idno>
                  <affiliation ref="#struct-1002311"/>
                  <affiliation ref="#struct-1002313"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Zimmermann</surname>
                  </persName>
                  <email type="md5">137f25d57be6b8e76139878e09f873b0</email>
                  <email type="domain">iaas.uni-stuttgart.de</email>
                  <idno type="idhal" notation="numeric">1096561</idno>
                  <idno type="halauthorid" notation="string">966002-1096561</idno>
                  <affiliation ref="#struct-572475"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gwen</forename>
                    <surname>Lomberk</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1196425</idno>
                  <idno type="halauthorid" notation="string">699041-1196425</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5463-789X</idno>
                  <affiliation ref="#struct-572475"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Raul</forename>
                    <surname>Urrutia</surname>
                  </persName>
                  <email type="md5">32340bd3be8c47f53466f16f2c45d197</email>
                  <email type="domain">mayo.edu</email>
                  <idno type="idhal" notation="numeric">938373</idno>
                  <idno type="halauthorid" notation="string">230298-938373</idno>
                  <affiliation ref="#struct-572475"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nelson</forename>
                    <surname>Dusetti</surname>
                  </persName>
                  <email type="md5">6be9233460a12de2672ab1281c3f9536</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">758392</idno>
                  <idno type="halauthorid" notation="string">220939-758392</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6161-8483</idno>
                  <idno type="IDREF">https://www.idref.fr/15184013X</idno>
                  <affiliation ref="#struct-179570"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yuna</forename>
                    <surname>Blum</surname>
                  </persName>
                  <email type="md5">0a45899a9c4261572ebe444bd94589d5</email>
                  <email type="domain">univ-rennes1.fr</email>
                  <idno type="idhal" notation="string">yuna-blum</idno>
                  <idno type="idhal" notation="numeric">1192321</idno>
                  <idno type="halauthorid" notation="string">444284-1192321</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4716-8017</idno>
                  <affiliation ref="#struct-187162"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rémy</forename>
                    <surname>Nicolle</surname>
                  </persName>
                  <email type="md5">fb8e8b172b7cb82f8d95909582c0616e</email>
                  <email type="domain">ligue-cancer.net</email>
                  <idno type="idhal" notation="string">remy-nicolle</idno>
                  <idno type="idhal" notation="numeric">774086</idno>
                  <idno type="halauthorid" notation="string">913694-774086</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8084-1173</idno>
                  <idno type="IDREF">https://www.idref.fr/199783926</idno>
                  <idno type="VIAF">https://viaf.org/viaf/182149717556610951654</idno>
                  <affiliation ref="#struct-1005007"/>
                  <affiliation ref="#struct-162876"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Juan</forename>
                    <surname>Iovanna</surname>
                  </persName>
                  <email type="md5">266a04f9ccecb3fdf64f1f955621cb15</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">932201</idno>
                  <idno type="halauthorid" notation="string">669529-932201</idno>
                  <affiliation ref="#struct-179570"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">105850</idno>
                <idno type="issn">2352-3964</idno>
                <title level="j">EBioMedicine</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">92</biblScope>
                  <biblScope unit="pp">104602</biblScope>
                  <date type="datePub">2023-05-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ebiom.2023.104602</idno>
              <idno type="pubmed">37148583</idno>
              <idno type="wos">000999663400001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Epidrugs</term>
                <term xml:lang="en">PDAC</term>
                <term xml:lang="en">Priming chemotherapies</term>
                <term xml:lang="en">Transcriptome</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: Systems biology leveraging multi-OMICs technologies, is rapidly advancing development of precision therapies and matching patients to targeted therapies, leading to improved responses. A new pillar of precision oncology lies in the power of chemogenomics to discover drugs that sensitizes malignant cells to other therapies. Here, we test a chemogenomic approach using epigenomic inhibitors (epidrugs) to reset patterns of gene expression driving the malignant behavior of pancreatic tumors. METHODS: We tested a targeted library of ten epidrugs targeting regulators of enhancers and super-enhancers on reprogramming gene expression networks in seventeen patient-derived primary pancreatic cancer cell cultures (PDPCCs), of both basal and classical subtypes. We subsequently evaluated the ability of these epidrugs to sensitize pancreatic cancer cells to five chemotherapeutic drugs that are clinically used for this malignancy. FINDINGS: To comprehend the impact of epidrug priming at the molecular level, we evaluated the effect of each epidrugs at the transcriptomic level of PDPCCs. The activating epidrugs showed a higher number of upregulated genes than the repressive epidrugs (χ(2) test p-value &amp;lt;0.01). Furthermore, we developed a classifier using the baseline transcriptome of epidrug-primed-chemosensitized PDPCCs to predict the best epidrug-priming regime to a given chemotherapy. Six signatures with a significant association with the chemosensitization centroid (R ≤ -0.80; p-value &amp;lt; 0.01) were identified and validated in a subset of PDPCCs. INTERPRETATION: We conclude that targeting enhancer-initiated pathways in patient-derived primary cells, represents a promising approach for developing new therapies for human pancreatic cancer.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-179570" status="VALID">
          <idno type="RNSR">201220152G</idno>
          <idno type="ROR">0494jpz02</idno>
          <orgName>Centre de Recherche en Cancérologie de Marseille</orgName>
          <orgName type="acronym">CRCM</orgName>
          <date type="start">2012</date>
          <desc>
            <address>
              <addrLine>27 bd Leï Roure, BP 30005913273 Marseille Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crcm.marseille.inserm.fr/spip.php?article314</ref>
          </desc>
          <listRelation>
            <relation name="UM105" active="#struct-198056" type="direct"/>
            <relation name="UMR7258" active="#struct-301325" type="direct"/>
            <relation active="#struct-301051" type="indirect"/>
            <relation name="U1068" active="#struct-303623" type="direct"/>
            <relation name="UMR7258" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-131288" status="VALID">
          <idno type="ROR">https://ror.org/0081fs513</idno>
          <orgName>Universidad de Buenos Aires [Buenos Aires]</orgName>
          <orgName type="acronym">UBA</orgName>
          <desc>
            <address>
              <addrLine>Viamonte 430/44 C1053ABJ,  Ciudad de Buenos Aires</addrLine>
              <country key="AR"/>
            </address>
            <ref type="url">http://www.uba.ar/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-321644" status="VALID">
          <orgName>Ligue Nationale Contre le Cancer</orgName>
          <orgName type="acronym">LNCC</orgName>
          <date type="start">2022-04-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-101" status="VALID">
          <idno type="IdRef">197370497</idno>
          <idno type="RNSR">200114730L</idno>
          <idno type="ROR">https://ror.org/00cjjmc56</idno>
          <orgName>Modélisation aléatoire de Paris X</orgName>
          <orgName type="acronym">MODAL'X</orgName>
          <date type="start">2001-01-01</date>
          <desc>
            <address>
              <addrLine>Université Paris NanterreModal'X, Bâtiment G200 avenue de la république,92000 NANTERRE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://modalx.parisnanterre.fr/</ref>
          </desc>
          <listRelation>
            <relation name="EA3454" active="#struct-116205" type="direct"/>
            <relation name="UMR9023" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002311" status="VALID">
          <idno type="RNSR">201119642G</idno>
          <idno type="ROR">https://ror.org/00780az30</idno>
          <orgName>Mathématiques et Informatique Appliquées</orgName>
          <orgName type="acronym">MIA Paris-Saclay</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>22 place de l'Agronomie CS 20040 91123 Palaiseau cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://mia-ps.inrae.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-148117" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UMR0518" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1002313" status="VALID">
          <idno type="RNSR">198017849T</idno>
          <idno type="ROR">https://ror.org/012fqzm33</idno>
          <orgName>Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale)</orgName>
          <orgName type="acronym">GQE-Le Moulon</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>UMR de Génétique Quantitative et Evolution - Le Moulon,   Ferme du Moulon F-91190 GIF SUR YVETTE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://moulon.inrae.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-148117" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UMR8120" active="#struct-441569" type="direct"/>
            <relation name="UMR0320" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-572475" status="VALID">
          <orgName>Medical College of Wisconsin [Milwaukee]</orgName>
          <orgName type="acronym">MCW</orgName>
          <desc>
            <address>
              <addrLine>8701 W Watertown Plank Rd, Wauwatosa, WI 53226, États-Unis</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.mcw.edu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-187162" status="VALID">
          <idno type="IdRef">178579254</idno>
          <idno type="ISNI">000000040609882X</idno>
          <idno type="RNSR">201220436R</idno>
          <idno type="ROR">https://ror.org/036xhtv26</idno>
          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://igdr.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="UMR6290" active="#struct-441569" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1005007" status="VALID">
          <idno type="IdRef">180760017</idno>
          <idno type="RNSR">201420703X</idno>
          <idno type="ROR">02gn50d10</idno>
          <orgName>Centre de recherche sur l'Inflammation</orgName>
          <orgName type="acronym">CRI (UMR_S_1149 / ERL_8252 / U1149)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine site Bichat - 16, Rue Henri Huchard - BP 416/4ème étage - 75870 Paris Cedex 18</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cri1149.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1149" active="#struct-303623" type="direct"/>
            <relation name="EMR8252 / ERL8252" active="#struct-441569" type="direct"/>
            <relation name="UMR_S_1149" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-162876" status="VALID">
          <orgName>(le programme) Cartes d'identité des tumeurs</orgName>
          <orgName type="acronym">CIT</orgName>
          <desc>
            <address>
              <addrLine>14, rue Corvisart - 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ligue-cancer.net/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-321644" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301325" status="VALID">
          <idno type="ROR">https://ror.org/04s3t1g37</idno>
          <orgName>Institut Paoli-Calmettes</orgName>
          <orgName type="acronym">IPC</orgName>
          <desc>
            <address>
              <addrLine>232 Boulevard de Sainte-Marguerite13009 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institutpaolicalmettes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301051" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301051" status="VALID">
          <orgName>Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-116205" status="VALID">
          <idno type="IdRef">026403587</idno>
          <idno type="ROR">https://ror.org/013bkhk48</idno>
          <orgName>Université Paris Nanterre</orgName>
          <orgName type="acronym">UPN</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>200 avenue de la République - 92001 Nanterre cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisnanterre.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-148117" status="VALID">
          <idno type="IdRef">139408088</idno>
          <idno type="ROR">https://ror.org/02kbmgc12</idno>
          <orgName>AgroParisTech</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>22 place de l'Agronomie CS 20040 91123 Palaiseau cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.agroparistech.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>