<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04098269</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T13:26:53+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors</title>
            <author role="aut">
              <persName>
                <forename type="first">Julie</forename>
                <surname>Terzic</surname>
              </persName>
              <email type="md5">ec69af220d1091f9f3095e508ff80742</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1249112</idno>
              <idno type="halauthorid" notation="string">1739052-1249112</idno>
              <affiliation ref="#struct-222993"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohamed</forename>
                <surname>Abu El Maaty</surname>
              </persName>
              <idno type="idhal" notation="numeric">813174</idno>
              <idno type="halauthorid" notation="string">2326713-813174</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8760-6376</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Régis</forename>
                <surname>Lutzing</surname>
              </persName>
              <email type="md5">a6637c90d9f5abf74a7951119c96af19</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1134029</idno>
              <idno type="halauthorid" notation="string">2323528-1134029</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9927-1825</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Vincent</surname>
              </persName>
              <email type="md5">e04b651d4b5cae600a4bd7962b8b4b18</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1254642</idno>
              <idno type="halauthorid" notation="string">32705-1254642</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rana</forename>
                <surname>El Bizri</surname>
              </persName>
              <email type="md5">cd4204058f668e67e71b98dcd6ba9b91</email>
              <email type="domain">etu.unistra.fr</email>
              <idno type="idhal" notation="numeric">1254643</idno>
              <idno type="halauthorid" notation="string">1739050-1254643</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4445-5045</idno>
              <idno type="IDREF">https://www.idref.fr/235717045</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matthieu</forename>
                <surname>Jung</surname>
              </persName>
              <email type="md5">736f0ba2da73f3ad71a12bf9f63d7854</email>
              <email type="domain">lirmm.fr</email>
              <idno type="idhal" notation="string">matthieu-jung</idno>
              <idno type="idhal" notation="numeric">1271944</idno>
              <idno type="halauthorid" notation="string">700116-1271944</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3272-7322</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Keime</surname>
              </persName>
              <email type="md5">ff564c7b9984ac72010180cc2f4dee58</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="string">celine-keime</idno>
              <idno type="idhal" notation="numeric">759094</idno>
              <idno type="halauthorid" notation="string">232198-759094</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7604-3814</idno>
              <idno type="IDREF">https://www.idref.fr/113134649</idno>
              <idno type="VIAF">https://viaf.org/viaf/200033256</idno>
              <idno type="ISNI">http://isni.org/isni/0000000357869738</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniel</forename>
                <surname>Metzger</surname>
              </persName>
              <email type="md5">77ddfcb0aa16545e20c7c33e22c2e7f0</email>
              <email type="domain">igbmc.fr</email>
              <idno type="idhal" notation="string">daniel-metzger</idno>
              <idno type="idhal" notation="numeric">180398</idno>
              <idno type="halauthorid" notation="string">1402-180398</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5555-046X</idno>
              <idno type="IDREF">https://www.idref.fr/086804901</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Archive ouverte</forename>
                <surname>univOAK</surname>
              </persName>
              <email type="md5">d35266c520c0e6b54ee7a42aa2ce7360</email>
              <email type="domain">unistra.fr</email>
            </editor>
            <funder ref="#projanr-49561"/>
            <funder ref="#projanr-54655"/>
            <funder ref="#projanr-49191"/>
            <funder ref="#projanr-37796"/>
            <funder ref="#projanr-55006"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-05-15 23:00:50</date>
              <date type="whenWritten">2023</date>
              <date type="whenModified">2026-01-28 10:28:38</date>
              <date type="whenReleased">2023-05-16 07:16:52</date>
              <date type="whenProduced">2023-04-18</date>
              <date type="whenEndEmbargoed">2023-05-15</date>
              <ref type="file" target="https://hal.science/hal-04098269v1/document">
                <date notBefore="2023-05-15"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04098269v1/file/islandora_162848.pdf" id="file-4098269-3568099">
                <date notBefore="2023-05-15"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="549677">
                <persName>
                  <forename>Archive ouverte</forename>
                  <surname>univOAK</surname>
                </persName>
                <email type="md5">d35266c520c0e6b54ee7a42aa2ce7360</email>
                <email type="domain">unistra.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04098269</idno>
            <idno type="halUri">https://hal.science/hal-04098269</idno>
            <idno type="halBibtex">terzic:hal-04098269</idno>
            <idno type="halRefHtml">&lt;i&gt;EMBO Molecular Medicine&lt;/i&gt;, 2023, &lt;a target="_blank" href="https://dx.doi.org/10.15252/emmm.202217209"&gt;&amp;#x27E8;10.15252/emmm.202217209&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">EMBO Molecular Medicine, 2023, &amp;#x27E8;10.15252/emmm.202217209&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4098269-3568099"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGBMC" corresp="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="FRANCE-GENOMIQUE">France Génomique</idno>
            <idno type="stamp" n="GENOMEAST" corresp="FRANCE-GENOMIQUE">GenomEast Platform</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="UNISTRA-ITI">Publications ITI Strasbourg</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Julie</forename>
                    <surname>Terzic</surname>
                  </persName>
                  <email type="md5">ec69af220d1091f9f3095e508ff80742</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1249112</idno>
                  <idno type="halauthorid" notation="string">1739052-1249112</idno>
                  <affiliation ref="#struct-222993"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohamed</forename>
                    <surname>Abu El Maaty</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">813174</idno>
                  <idno type="halauthorid" notation="string">2326713-813174</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8760-6376</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Régis</forename>
                    <surname>Lutzing</surname>
                  </persName>
                  <email type="md5">a6637c90d9f5abf74a7951119c96af19</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1134029</idno>
                  <idno type="halauthorid" notation="string">2323528-1134029</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9927-1825</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Vincent</surname>
                  </persName>
                  <email type="md5">e04b651d4b5cae600a4bd7962b8b4b18</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1254642</idno>
                  <idno type="halauthorid" notation="string">32705-1254642</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rana</forename>
                    <surname>El Bizri</surname>
                  </persName>
                  <email type="md5">cd4204058f668e67e71b98dcd6ba9b91</email>
                  <email type="domain">etu.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1254643</idno>
                  <idno type="halauthorid" notation="string">1739050-1254643</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4445-5045</idno>
                  <idno type="IDREF">https://www.idref.fr/235717045</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthieu</forename>
                    <surname>Jung</surname>
                  </persName>
                  <email type="md5">736f0ba2da73f3ad71a12bf9f63d7854</email>
                  <email type="domain">lirmm.fr</email>
                  <idno type="idhal" notation="string">matthieu-jung</idno>
                  <idno type="idhal" notation="numeric">1271944</idno>
                  <idno type="halauthorid" notation="string">700116-1271944</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3272-7322</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Keime</surname>
                  </persName>
                  <email type="md5">ff564c7b9984ac72010180cc2f4dee58</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="string">celine-keime</idno>
                  <idno type="idhal" notation="numeric">759094</idno>
                  <idno type="halauthorid" notation="string">232198-759094</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7604-3814</idno>
                  <idno type="IDREF">https://www.idref.fr/113134649</idno>
                  <idno type="VIAF">https://viaf.org/viaf/200033256</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000357869738</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniel</forename>
                    <surname>Metzger</surname>
                  </persName>
                  <email type="md5">77ddfcb0aa16545e20c7c33e22c2e7f0</email>
                  <email type="domain">igbmc.fr</email>
                  <idno type="idhal" notation="string">daniel-metzger</idno>
                  <idno type="idhal" notation="numeric">180398</idno>
                  <idno type="halauthorid" notation="string">1402-180398</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5555-046X</idno>
                  <idno type="IDREF">https://www.idref.fr/086804901</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">65171</idno>
                <idno type="issn">1757-4676</idno>
                <idno type="eissn">1757-4684</idno>
                <title level="j">EMBO Molecular Medicine</title>
                <imprint>
                  <publisher>Wiley Open Access</publisher>
                  <date type="datePub">2023-04-18</date>
                </imprint>
              </monogr>
              <idno type="doi">10.15252/emmm.202217209</idno>
              <ref type="publisher">https://www.embopress.org/journal/17574684</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">PTEN, castration-resistant prostate cancer, genetically-engineered mice, HIF1A, single-cell RNA sequencing</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Androgen deprivation therapy (ADT) is a cornerstone of prostate cancer (PCa) management. Although tumors initially regress, many progress to a hormone-independent state termed castration-resistant PCa (CRPC), for which treatment options are limited. We here report that the major luminal cell population in tumors of Pten(i)pe-/- mice, generated by luminal epithelial cell-specific deletion of the tumor suppressor PTEN after puberty, is castration-resistant and that the expression of inflammation and stemness markers is enhanced in persistent luminal cells. In addition, hypoxia-inducible factor 1 (HIF1) signaling, which we have previously demonstrated to be induced in luminal cells of Pten(i)pe-/- mice and to promote malignant progression, is further activated. Importantly, we show that genetic and pharmacological inhibition of HIF1A sensitizes Pten-deficient prostatic tumors to castration and provides durable therapeutic responses. Furthermore, HIF1A inhibition induces apoptotic signaling in human CRPC cell lines. Therefore, our data demonstrate that HIF1A in prostatic tumor cells is a critical factor that enables their survival after ADT, and identify it as a target for CRPC management.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-222993" status="VALID">
          <idno type="IdRef">175164703</idno>
          <idno type="RNSR">201320503J</idno>
          <idno type="ROR">https://ror.org/03k7yrw82</idno>
          <orgName>Immuno-Rhumatologie Moléculaire</orgName>
          <orgName type="acronym">IRM</orgName>
          <desc>
            <address>
              <addrLine>1 Place de l'Hôpital 67000 Strasbourg</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://u1109.inserm.fr</ref>
          </desc>
          <listRelation>
            <relation name="UMRS1109" active="#struct-199013" type="direct"/>
            <relation name="U1109" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-93800" status="VALID">
          <idno type="IdRef">155263749</idno>
          <idno type="ISNI">0000 0004 0638 2716</idno>
          <idno type="RNSR">200112491C</idno>
          <idno type="ROR">https://ror.org/0015ws592</idno>
          <idno type="Wikidata">Q3152004</idno>
          <orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName>
          <orgName type="acronym">IGBMC</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igbmc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS964" active="#struct-199013" type="direct"/>
            <relation name="U1258" active="#struct-303623" type="direct"/>
            <relation name="UMR7104" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-49561" status="VALID">
          <idno type="anr">ANR-17-EURE-0023</idno>
          <orgName>IMCBio</orgName>
          <desc>Integrative Molecular and Cellular Biology</desc>
          <date type="start">2017</date>
        </org>
        <org type="anrProject" xml:id="projanr-54655" status="VALID">
          <idno type="anr">ANR-20-SFRI-0012</idno>
          <orgName>STRAT'US</orgName>
          <desc>Façonner les talents en formation et en recherche à l'Université de Strasbourg</desc>
          <date type="start">2020</date>
        </org>
        <org type="anrProject" xml:id="projanr-49191" status="VALID">
          <idno type="anr">ANR-10-INBS-0009</idno>
          <orgName>France Génomique</orgName>
          <desc>Organisation et montée en puissance d'une Infrastructure Nationale de Génomique</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-37796" status="VALID">
          <idno type="anr">ANR-10-IDEX-0002</idno>
          <idno type="program">Initiative d'excellence</idno>
          <orgName>UNISTRA</orgName>
          <desc>Par-delà les frontières, l'Université de Strasbourg</desc>
          <date type="start">2010</date>
        </org>
        <org type="anrProject" xml:id="projanr-55006" status="VALID">
          <idno type="anr">ANR-10-LABX-0030</idno>
          <orgName>INRT</orgName>
          <desc>Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>