Current mass balance and meteorological surveys of Mera glacier located about 30 km south of Mount Everest in Nepal show the dominant role of Asian monsoon precipitation on interannual mass balance variability while temperature controls the altitude of snow-rain threshold. As these observations on mass balance variability only explore the recent decades, studies on paleo glacial extents are useful to investigate the long-term climate forcing on glacier evolution. To do so, we investigated the long-term evolution of the debris-free Mera glacier and a neighbouring small debris-free South Khare glacier. Fifty-one 10Be CRE ages were obtained from samples collected on moraine boulders and roches moutonnées. 10Be CRE ages of the boulders span from the end of the Lateglacial (19.0–11.7 ka) to the Little Ice Age (∼0.6–0.1 ka). The oldest dated moraine in this study was observed at the base of South Khare glacier with an age of 13.6 ± 0.5 ka. The two glaciers subsequently experienced their largest Holocene extent in the Early Holocene with moraines dated to 11.0 ± 0.3 ka at the base of Mera glacier and 10.8 ± 0.5 ka at the base of South Khare glacier. We did not observe any moraine from the Mid-Holocene. During the Late Holocene several glacier advances were recorded around 2.3 ± 0.2 ka, 1.5 ka and then during the last centuries at Mera glacier and around 2.8 ± 0.6 ka, and during the Little Ice Age at South Khare glacier. To explore the links between long-term Nepalese glacier changes and climate, we used oceanic and terrestrial Indian Summer monsoon reconstructions and temperature and precipitation output from two transient global climate models TraCE and LOVECLIM. These climate data outputs were corrected by a reconstruction of the Atlantic Meridional Overturning Circulation (AMOC) over the Holocene and its associated climatic impacts. We also used sensitivity experiments from the IPSL (Institut Pierre Simon Laplace) model to discuss the possible influence of horizontal resolution, land hydrology, vegetation and runoff on changes in Asian summer monsoon. Importantly, we show this long-term Nepalese glacier pattern does not perfectly conform neither to the Indian monsoon precipitation that is documented from terrestrial and marine records nor to temperature and precipitation changes simulated by the models. While the maximum glacier extent in the Early Holocene corresponds to enhanced precipitation documented by proxies and models, the Late Holocene glacier advance remains puzzling. We claim that new paleo glacier records and improved climate simulations are necessary to get a better understanding of past glacier changes and the associated climate dynamics, which might be crucial to gain confidence in both glacier and climate future evolutions.