AbstractVarious catalytic reactions under suitable conditions were used for the carbon-carbon (C-C) bond formation, such as the Kumada, Mizoroki-Heck, Sonogashira, Negishi, Stille, Suzuki-Miyaura, Hiyama, andFukuyama cross-coupling reactions. Supporting metal nanoparticles or complexes on functionalizedgraphene oxide (GO) or reduced graphene oxide (rGO) compounds provides new heterogeneous catalysts with enhanced aptitude for the formation of C-C bonds. This review highlights the applications ofmetal decorated on modified GO and rGO derivatives to form C-C bonds. We discuss briefly the generalmechanistic cycle of each reaction and the recent applications of the graphene-based nanocatalysts forthe coupling reactions, along the advantages of each catalyst.