External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium - Archive ouverte HAL Access content directly
Journal Articles Annals of the New York Academy of Sciences Year : 2001

External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium

Abstract

The process of fetal external genitalia development might be divided into two processes. The first process accomplishes the initial outgrowth of the anlage, genital tubercle (GT). Previous analysis suggests that the distal urethral epithelium (DUE) of the GT, the Fgf8-expressing region, regulates the outgrowth of the GT. The second process eventually generates the sexually dimorphic development of the external genitalia, which is dependent on the action of steroid hormones. Several key genes, for example, RARs, RXRs, RALDH2, and CYP26, were dynamically expressed during GT development. The teratogenic dose of RA at 9.0 d.p.c. induced a drastic malformation of the urethral plate during GT formation, but did not show gross abnormalities in its outgrowth. In RA-treated embryos, Fgf8 expression was still detected in the distal GT regions. Possible regulatory roles of the FGF and RA signaling systems in external genitalia formation are discussed.

Dates and versions

hal-04093220 , version 1 (09-05-2023)

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Yukiko Ogino, Kentaro Suzuki, Ryuma Haraguchi, Yoshihiko Satoh, Pascal Dollé, et al.. External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. Annals of the New York Academy of Sciences, 2001, 948, pp.13-31. ⟨10.1111/j.1749-6632.2001.tb03983.x⟩. ⟨hal-04093220⟩
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