Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent - Archive ouverte HAL
Article Dans Une Revue Inorganic Chemistry Année : 2020

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent

Justin Weynand
Angélica Moreno-Betancourt
  • Fonction : Auteur
Nathalie Berthet
Eric Defrancq

Résumé

The development of new photoactive metal complexes that can trigger oxidative damages to the genetic material is of great interest. In the present paper, we describe the detailed study of a highly photo-oxidant iridium(III) complex that triggers photoinduced electron transfer (PET) with purine DNA bases. The PET has been studied by luminescence and laser flash photolysis experiments. From plasmid DNA agarose gel electrophoresis experiments, we demonstrated the high ability of the iridium complex to induce strand breaks upon light irradiation. Reactive oxygen species (ROS)-specific scavengers and stabilizers were employed to identify that the photocleavage process, the results of which infer singlet oxygen and hydrogen peroxide as the predominant species. To the best of our knowledge, the present work represents one of the few study for highly photo-oxidant bis-cyclometalated iridium(III) complex toward DNA.
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Dates et versions

hal-04092051 , version 1 (09-05-2023)

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Citer

Justin Weynand, Angélica Moreno-Betancourt, Frédérique Loiseau, Nathalie Berthet, Eric Defrancq, et al.. Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent. Inorganic Chemistry, 2020, 59 (4), pp.2426-2433. ⟨10.1021/acs.inorgchem.9b03312⟩. ⟨hal-04092051⟩
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