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Journal Articles Cortex Year : 2023

The origin of pleasant sensations: Insight from direct electrical brain stimulation

Abstract

Research into the neuroanatomical basis of emotions has resulted in a plethora of studies over the last twenty years. However, studies about positive emotions and pleasant sensations remain rare and their anatomical-functional bases are less understood than that of negative emotions. Pleasant sensations can be evoked by electrical brain stimulations (EBS) during stereotactic electroencephalography (SEEG) performed for pre-surgical exploration in patients with drug-resistant epilepsy. We conducted a retrospective analysis of 10 106 EBS performed in 329 patients implanted with SEEG in our epileptology department. We found that 13 EBS in 9 different patients evoked pleasant sensations (.60% of all responses). By contrast we collected 111 emotional responses of negative valence (i.e., 5.13% of all responses). EBS evoking pleasant sensations were applied at 50 Hz with an average intensity of 1.4 ± .55 mA (range .5e2 mA). Pleasant sensations were reported by nine patients of which three patients presented responses to several EBS. We found a male predominance among the patients reporting pleasant sensations and a prominent role of the right cerebral hemisphere. Results show the preponderant role of the dorsal anterior insula and amygdala in the occurrence of pleasant sensations.
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hal-04088305 , version 1 (04-05-2023)

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Cécile Villard, Zoé Dary, Jacques Léonard, Samuel Medina Villalon, Romain Carron, et al.. The origin of pleasant sensations: Insight from direct electrical brain stimulation. Cortex, 2023, 164, pp.1-10. ⟨10.1016/j.cortex.2023.03.007⟩. ⟨hal-04088305⟩
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