Neural interactions in the human frontal cortex dissociate reward and punishment learning - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail (Preprint/Prepublication) Année : 2023

Neural interactions in the human frontal cortex dissociate reward and punishment learning

Etienne Combrisson
Ruggero Basanisi
Maelle Gueguen
Sylvain Rheims
Philippe Kahane
Julien Bastin
Andrea Brovelli

Résumé

How human prefrontal and insular regions interact while maximizing rewards and minimizing punishments is unknown. Capitalizing on human intracranial recordings, we demonstrate that the functional specificity toward reward or punishment learning is better disentangled by interactions compared to local representations. Prefrontal and insular cortices display non-selective neural populations to reward and punishment. The non-selective responses, however, give rise to context-specific interareal interactions. We identify a reward subsystem with redundant interactions between the orbitofrontal and ventromedial prefrontal cortices, with a driving role of the latter. In addition, we find a punishment subsystem with redundant interactions between the insular and dorsolateral cortices, with a driving role of the insula. Finally, switching between reward and punishment learning is mediated by synergistic interactions between the two subsystems. These results provide a unifying explanation of distributed cortical representations and interactions supporting reward and punishment learning.

Domaines

Neurosciences

Dates et versions

hal-04088268 , version 1 (04-05-2023)

Identifiants

Citer

Etienne Combrisson, Ruggero Basanisi, Maelle Gueguen, Sylvain Rheims, Philippe Kahane, et al.. Neural interactions in the human frontal cortex dissociate reward and punishment learning. 2023. ⟨hal-04088268⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More