Hyperpolarized NMR metabolomics - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Current Opinion in Chemical Biology Année : 2023

Hyperpolarized NMR metabolomics

Résumé

Hyperpolarized NMR is a promising approach to address the sensitivity limits of conventional NMR metabolomics approaches, which currently fails to detect minute metabolite concentrations in biological samples. This review describes how tremendous signal enhancement offered by dissolution-dynamic nuclear polarization and parahydrogen-based techniques can be fully exploited for molecular omics sciences. Recent developments, including the combination of hyperpolarization techniques with fast multi-dimensional NMR implementation and quantitative workflows are described, and a comprehensive comparison of existing hyperpolarization techniques is proposed. High-throughput, sensitivity, resolution and other relevant challenges that should be tackled for a general application of hyperpolarized NMR in metabolomics are discussed.
Fichier principal
Vignette du fichier
Accepted manuscript Ribay COCHBI 2023.pdf (824.96 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04086586 , version 1 (02-05-2023)

Identifiants

Citer

Victor Ribay, Clément Praud, Marine P.M. Letertre, Jean-Nicolas Dumez, Patrick Giraudeau. Hyperpolarized NMR metabolomics. Current Opinion in Chemical Biology, 2023, 74, pp.102307. ⟨10.1016/j.cbpa.2023.102307⟩. ⟨hal-04086586⟩
36 Consultations
40 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More