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Article Dans Une Revue Journal of materials chemistry‎ B Année : 2023

Hierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines

Simona Mura
Florent Carn
Florence Gazeau
Eddy Dumas
Christian Serre

Résumé

Among a plethora of drug nanocarriers, biocompatible nanoscale metal-organic frameworks (nanoMOFs) with a large surface area and an amphiphilic internal microenvironment have emerged as promising drug delivery platforms, mainly for cancer therapy. However, their application in biomedicine still suffers from shortcomings such as a limited chemical and/or colloidal stability and/or toxicity. Here, we report the design of a hierarchically porous nano-object (denoted as USPIO@MIL) combining a benchmark nanoMOF (that is, MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (that is, maghemite) that is synthesized through a one-pot, cost-effective and environmentally friendly protocol. The synergistic coupling of the physico-chemical and functional properties of both nanoparticles confers to these nano-objects valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity as well as stimuli-responsive drug release and superparamagnetic properties. This bimodal MIL-100(Fe)/maghemite nanocarrier once loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate) shows high anti-inflammatory and anti-tumoral activities. In addition, the USPIO@MIL nano-object exhibits excellent relaxometric properties and its applicability as an efficient contrast agent for magnetic resonance imaging is herein demonstrated. This highlights the high potential of the maghemite@MOF composite integrating the functions of imaging and therapy as a theranostic anti-inflammatory formulation.

Domaines

Chimie
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Dates et versions

hal-04068864 , version 1 (18-04-2023)

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Heng Zhao, Saad Sene, Angelika Mielcarek, Sylvain Miraux, Nicolas Menguy, et al.. Hierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines. Journal of materials chemistry‎ B, 2023, 11 (14), pp.3195-3211. ⟨10.1039/d2tb02094g⟩. ⟨hal-04068864⟩
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